The specific inhibitor, N-diazoacetylnorleucine methyl ester reacts stoicheiometrically with bovine pepsin resulting in a simultaneous loss of all enzymic activity. A peptide containing a modified aspartyl group was isolated from bovine pepsin labelled with 14C-labelled inhibitor. The aspartic acid residue is presumed to be part of the active centre and is in the same heptapeptide sequence as in porcine pepsin: Ile-Val-Asp-Thr-Gly-Thr-Ser.
Research Article|October 01 1971
Bovine pepsinogens and pepsins. The sequence around a reactive aspartyl residue
Biochem J (1971) 124 (4): 673-676.
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Patricia A. Meitner; Bovine pepsinogens and pepsins. The sequence around a reactive aspartyl residue. Biochem J 1 October 1971; 124 (4): 673–676. doi: https://doi.org/10.1042/bj1240673
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