1. Two protocollagen model peptides, Z-Gly-Pro-Hyp-Gly-(Pro-Pro-Gly)5 (Z, benzyloxycarbonyl) and AOC-(Pro-Pro-Gly)6 (AOC, tert.-pentyloxycarbonyl), were synthesized and hydroxylated with protocollagen proline hydroxylase. 2. The two model peptides were hydroxylated equally. The results suggest that the hydroxyl group of hydroxyproline contained in the N-terminal region of the peptide has no effect on the enzymic hydroxylation of the model peptide.
Research Article|October 01 1971
Synthesis and enzymic hydroxylation of protocollagen model peptide containing a hydroxyproline residue
Biochem J (1971) 124 (4): 695-700.
- Views Icon Views
- PDF LinkPDF
- Share Icon Share
- Cite Icon Cite
Y. Kikuchi, D. Fujimoto, N. Tamiya; Synthesis and enzymic hydroxylation of protocollagen model peptide containing a hydroxyproline residue. Biochem J 1 October 1971; 124 (4): 695–700. doi: https://doi.org/10.1042/bj1240695
Download citation file: