The kinetics of the influx and efflux of radioactive l-glycine was studied in slices of rat cerebral cortex. The influx showed saturation kinetics and was inhibited by l-alanine. Influx was dependent on the presence of Na+ ions and a metabolizable substrate. The efflux of glycine was accelerated by alanine. It was concluded that carrier-mediated facilitated diffusion was the mechanism of glycine uptake by, and efflux from, cerebral slices.
Research Article|November 01 1971
The uptake and efflux of glycine from rat cerebral-cortex slices
Biochem J (1971) 125 (1): 255-260.
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P. Joanny, E. Barbosa, H. Hillman, J. Corriol; The uptake and efflux of glycine from rat cerebral-cortex slices. Biochem J 1 November 1971; 125 (1): 255–260. doi: https://doi.org/10.1042/bj1250255
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