1. The time-course of the effects of ethanol administration on the metabolite concentrations, redox states and phosphorylation state was studied in the freeze-clamped liver of starved rats. The response was found to vary with the time after ethanol administration. 2. Administration of ethanol caused an immediate decrease in the [NAD+]/[NADH] ratio of both cytoplasm and mitochondria, which persisted over the 30min studied. 3. The free cytoplasmic [NADP+]/[NADPH] ratio in liver decreases immediately after ethanol administration but returns nearly to control values after 15min. 4. The cytoplasmic [ATP]/[ADP][HPO42-] ratio is elevated 15min after ethanol administration in the starved rat. 5. The rapid and large changes in most metabolite concentrations measured appeared to result from the maintenance of near-equilibrium in a wide interlinked network. 6. Differences between fed and starved rats 15min after ethanol administration were slight.
Research Article|April 01 1972
The time-course of the effects of ethanol on the redox and phosphorylation states of rat liver
R. L. Veech;
Biochem J (1972) 127 (2): 387-397.
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R. L. Veech, R. Guynn, D. Veloso; The time-course of the effects of ethanol on the redox and phosphorylation states of rat liver. Biochem J 1 April 1972; 127 (2): 387–397. doi: https://doi.org/10.1042/bj1270387
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