1. The type-specific substance, S.13, from Pneumococcus type 13 was subjected to hydrolysis with alkali, followed by enzymic dephosphorylation, to yield a pentasaccharide. 2. The pentasaccharide, corresponding to the dephosphorylated repeating unit of S.13, was shown to be O-β-d-galactopyranosyl-(1→4)-O-β- d-glucopyranosyl-(1→3)-O-β-d- galactofuranosyl-(1→4)-O-2-acetamido-2-deoxy-β-d- glucopyranosyl-(1→2)-ribitol. 3. The phosphodiester linkages in S.13 join the hydroxyl group at position 1 of ribitol and the hydroxyl group at position 4 of a galactopyranosyl residue in the next repeating unit. 4. Ester groups, presumably O-acetyl, are located on positions 2 or 3 of most glucopyranosyl residues in S.13. 5. A partial structure for S.13 is proposed.
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November 1972
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Research Article|
November 01 1972
The type-specific substance from Pneumococcus type 13
M. J. Watson;
M. J. Watson
1Microbiological Chemistry Research Laboratory, Department of Organic Chemistry, University of Newcastle upon Tyne, Newcastle NE1 7RU, U.K.
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Jean M. Tyler;
Jean M. Tyler
1Microbiological Chemistry Research Laboratory, Department of Organic Chemistry, University of Newcastle upon Tyne, Newcastle NE1 7RU, U.K.
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J. G. Buchanan;
J. G. Buchanan
1Microbiological Chemistry Research Laboratory, Department of Organic Chemistry, University of Newcastle upon Tyne, Newcastle NE1 7RU, U.K.
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J. Baddiley
J. Baddiley
1Microbiological Chemistry Research Laboratory, Department of Organic Chemistry, University of Newcastle upon Tyne, Newcastle NE1 7RU, U.K.
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Publisher: Portland Press Ltd
© 1972 The Biochemical Society
1972
Biochem J (1972) 130 (1): 45–54.
Citation
M. J. Watson, Jean M. Tyler, J. G. Buchanan, J. Baddiley; The type-specific substance from Pneumococcus type 13. Biochem J 1 November 1972; 130 (1): 45–54. doi: https://doi.org/10.1042/bj1300045
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