Iron-deficient rats excreted greater amounts of 5-aminolaevulinate in urine but the output of porphobilinogen was decreased considerably. In addition, activity of the enzyme 5-aminolaevulinate dehydratase was diminished in bone marrow and liver. The results suggest that in iron deficiency a defect occurs in porphyrin synthesis at the level of porphobilinogen formation.
Research Article|July 15 1973
Aberration of porphyrin metabolism in iron-deficient anaemic rats (Short Communication)
Biochem J (1973) 134 (3): 821-823.
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Dinesh C. Sharma; Aberration of porphyrin metabolism in iron-deficient anaemic rats (Short Communication). Biochem J 15 July 1973; 134 (3): 821–823. doi: https://doi.org/10.1042/bj1340821
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