Fractions highly enriched in plasma membrane, endoplasmic reticulum or brush border were prepared from homogenized rat kidney cortex. Kallikrein was concentrated in the plasma-membrane fraction, but not in the brush border of the proximal tubules. Kininase II or angiotensin I-converting enzyme was localized in the brush-border membrane. It is suggested that kallikrein in the urine may originate from the plasma membrane of the distal tubules and the conversion of angiotensin I and the inactivation of bradykinin may occur on the lumen membrane of the proximal tubular cells.
Research Article|December 01 1975
Isolation of membrane-bound renal kallikrein and kininase
P E Ward;
C D Gedney;
R M Dowben;
Biochem J (1975) 151 (3): 755-758.
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P E Ward, C D Gedney, R M Dowben, E G Erdös; Isolation of membrane-bound renal kallikrein and kininase. Biochem J 1 December 1975; 151 (3): 755–758. doi: https://doi.org/10.1042/bj1510755
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