Natural or early weaning of rat litters caused an increased activity of maternal luteal 20α-hydroxy steroid dehydrogenase and a decreased release of delta4-3-oxo steroids in vitro. 2. Compound CB-154 (2-bromo-α-ergocryptine) caused an increase of 20α-hydroxy steroid dehydrogenase activity in mid-lactation but not in early lactation. 3. Prolaction did not prevent these increases in enzyme activity.

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