C-6 glial cells were shown to contain enriched in their plasma membranes an enzyme, 2′:3′-cyclic nucleotide 3′-phosphohydrolase, characteristic of myelin, and, in addition, proteolipid protein and two basic proteins that are identical in their electrophoretic mobilities with the respective proteins found in myelin. The data indicate that C-6 cells exhibit features of myelin-producing glia as well as astrocytes.

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