When isolated fat-cells are incubated at 25 degrees C in serum-based media containing glucose, insulin and heparin, the rise that occurs in the clearing-factor lipase activity of the incubation medium is inhibited by colchicine. The rise in the fat-cell clearing-factor lipase activity that occurs during similar incubations in the absence of heparin is not affected by colchicine.
Colchicine inhibition of the heparin-stimulated release of clearing-factor lipase from isolated fat-cells
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A Cryer, A McDonald, E R Williams, D S Robinson; Colchicine inhibition of the heparin-stimulated release of clearing-factor lipase from isolated fat-cells. Biochem J 1 December 1975; 152 (3): 717–720. doi: https://doi.org/10.1042/bj1520717
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