By using the X-ray-diffraction results reported previously for sodium heparan sulphate, a twofold helical conformation with an axially projected disaccharide repeat (h) equal to 0.93 nm has been examined in detail. On the basis of a repeating sequence of 1,4-alpha-D-glucosamine and 1,4-beta-D-glucuronic acid, trial and stereochemically feasible molecular models were computer-generated. An optimum twofold helical conformation is proposed, incorporating stabilizing intra-chain hydrogen bonds across both glycosidic linkages.
Research Article|March 01 1977
Molecular conformation of sodium heparan sulphate in the condensed phase
Biochem J (1977) 161 (3): 495-498.
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H F Elloway, E D T Atkins; Molecular conformation of sodium heparan sulphate in the condensed phase. Biochem J 1 March 1977; 161 (3): 495–498. doi: https://doi.org/10.1042/bj1610495
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