Administration of acetoactate to fed lactating rats rapidly decreases glucose uptake by the mammary gland, and causes an output of pyruvate, whereas lactate uptake remains unchanged. Similar changes, though not identical, occur in starved lactating rats, which suggests that the increased acetoacetate concentration in this situation may be one of the factors responsible for the alterations in glucose metabolism.
Research Article|June 15 1977
Effects of acetoacetate administration on glucose metabolism in mammary gland of fed lactating rats
Biochem J (1977) 164 (3): 749-752.
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A M Robinson, D H Williamson; Effects of acetoacetate administration on glucose metabolism in mammary gland of fed lactating rats. Biochem J 15 June 1977; 164 (3): 749–752. doi: https://doi.org/10.1042/bj1640749
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