In hyperthyroid chicks, oestrogen-induced plasma accumulation of riboflavin-binding protein was diminished, whereas the reverse situation prevailed in hypothyroid birds. Under hyperthyroid conditions, higher concentrations of oestrogen were required to elicit a response comparable with that obtained in normal birds treated with lower concentrations of the hormone. Elevated hepatic cytochrome P-450 concentrations and decreased half-life of the induced protein in hyperthyroid animals suggest that higher catabolic rates of the inducer and induced protein are contributory factors to the diminished response.
Research Article|September 15 1977
Oestrogen induction of riboflavin-binding protein in immature chicks
Biochem J (1977) 166 (3): 647-650.
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U S Murthy, P R Adiga; Oestrogen induction of riboflavin-binding protein in immature chicks. Biochem J 15 September 1977; 166 (3): 647–650. doi: https://doi.org/10.1042/bj1660647
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