3-Phenylpyruvate evoked a monophasic insulin release from perifused mouse islets. L-Phenylalanine was not an insulin secretagogue and was oxidized by islets at a very low rate, suggesting that 3-phenylpyruvate does not trigger insulin release by enhancing production of reducing equivalents. Moreover, allosteric activation of glutamate dehydrogenase does not play a role in 3-phenylpyruvate-induced insulin secretion.
Research Article|August 15 1981
Mechanism of 3-phenylpyruvate-induced insulin release from isolated pancreatic islets
Biochem J (1981) 198 (2): 353-356.
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U Panten, J Langer; Mechanism of 3-phenylpyruvate-induced insulin release from isolated pancreatic islets. Biochem J 15 August 1981; 198 (2): 353–356. doi: https://doi.org/10.1042/bj1980353
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