The role of foetal glutamate as a source of placental glutamine was investigated in the near-term pregnant guinea-pig placenta perfused in situ through the umbilical vessels. With normal foetal amino acid concentrations there was a significant two-way exchange of glutamate between the placenta and foetal perfusate, but a net release of the amino acid from the placenta. Radioactively labelled glutamate carbon entering the placenta by this exchange was freely incorporated into intracellular glutamine, but only 1.5% of it was found in glutamine transported out into the foetal circulation. In the guinea pig, therefore, foetal glutamate does not appear to be a precursor of glutamine released from the placenta on the foetal side.
Research Article|August 15 1981
Foetal glutamate as a possible precursor of placental glutamine in the guinea pig
Biochem J (1981) 198 (2): 397-401.
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D L Bloxam, C F Tyler, M Young; Foetal glutamate as a possible precursor of placental glutamine in the guinea pig. Biochem J 15 August 1981; 198 (2): 397–401. doi: https://doi.org/10.1042/bj1980397
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