The ratio of ATP content/ADP content in livers from unanaesthetized fed rat was 0.9 in the mitochondrial matrix and 6.9 in the cytosol; the values for starved (48 h) animals were 1.0 and 5.9 respectively. The mitochondrial ratios observed in unanaesthetized animals were higher than in haemoglobin-free-perfused liver and lower than in isolated hepatocytes. Possible reasons for these differences may be related to oxygen supply and/or other factors. Further, data from anaesthetized rats with the liver exposed are given: mitochondrial ATP/ADP ratios were decreased with pentobarbital, but less so with ketamine as narcotic agent.
Research Article|November 15 1981
Mitochondrial and cytosolic ATP/ADP ratios in rat liver in vivo
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Biochem J (1981) 200 (2): 405-408.
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W D Schwenke, S Soboll, H J Seitz, H Sies; Mitochondrial and cytosolic ATP/ADP ratios in rat liver in vivo. Biochem J 15 November 1981; 200 (2): 405–408. doi: https://doi.org/10.1042/bj2000405
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