A specific 1,25-dihydroxycholecalciferol-binding protein has been detected in high-salt cytosols prepared from human medullary thyroid carcinomas. The binding protein had the same equilibrium dissociation constant (Kd = 0.17 +/- 0.05 nM; n = 4) and sedimentation coefficient on sucrose gradients (3.7S) as than seen in established vitamin D target tissues. This protein was not detected in normal thyroid cytosols, which may reflect the low proportion of C-cells within the gland.
Research Article| July 15 1982
Specific binding of 1,25-dihydroxycholecalciferol in human medullary thyroid carcinoma
Biochem J (1982) 206 (1): 181–184.
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H C Freake, I MacIntyre; Specific binding of 1,25-dihydroxycholecalciferol in human medullary thyroid carcinoma. Biochem J 15 July 1982; 206 (1): 181–184. doi: https://doi.org/10.1042/bj2060181
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