The administration of an oral glucose load to 24 h-starved lean (+/?) male C57BL/6 mice produced a rapid, 7-fold increase in the rate of hepatic glycogen synthesis and a sustained activation of glycogen synthase. In contrast, glucose produced only a small (4.5-fold), short-lived increase in hepatic glycogen synthesis in genetically obese (ob/ob) mice and no activation of glycogen synthase.
Defective activation by glucose of hepatic glycogen synthesis in the obese hyperglycaemic mouse
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S A Smith, M A Cawthorne, A L Levy, D L Simson; Defective activation by glucose of hepatic glycogen synthesis in the obese hyperglycaemic mouse. Biochem J 15 November 1983; 216 (2): 491–494. doi: https://doi.org/10.1042/bj2160491
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