At micromolar concentrations, acetyl-CoA inhibited hepatic carnitine acyltransferase activity and mitochondrial fatty acid oxidation. The inhibitory effects were not nearly as potent on a molar basis as those of malonyl-CoA; nevertheless, the cytosolic concentrations of acetyl-CoA, as yet unknown, may be sufficient (greater than 30 microM) to curtail appreciably the mitochondrial transfer of long-chain acyl-CoA units and fatty acid oxidation. Hence acetyl-CoA may also partially regulate hepatic ketogenesis.
Research Article|November 15 1983
Inhibition by acetyl-CoA of hepatic carnitine acyltransferase and fatty acid oxidation
V J Notar-Francesco;
Biochem J (1983) 216 (2): 499-502.
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K McCormick, V J Notar-Francesco, K Sriwatanakul; Inhibition by acetyl-CoA of hepatic carnitine acyltransferase and fatty acid oxidation. Biochem J 15 November 1983; 216 (2): 499–502. doi: https://doi.org/10.1042/bj2160499
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