Lactating rats were starved for 48 h and refed a high-carbohydrate diet for a further 48 h. Starvation stops milk secretion, which resumes shortly after refeeding. Three lipogenic enzymes, fatty acid synthase, glucose 6-phosphate dehydrogenase (EC 220.127.116.11) and ‘malic’ enzyme (EC 18.104.22.168) all decrease in the mammary gland during starvation and are restored to the pre-starvation levels 48 h after refeeding. The same enzymes in liver also decrease during starvation, but increase to values significantly higher than those for the normal fed rats after refeeding the high-carbohydrate diet. For the fatty acid synthase these values were four times the pre-starvation values. Serum insulin and prolactin concentrations also increased upon refeeding the high-carbohydrate diet.
Research Article|November 15 1983
The effect of starvation and refeeding on lipogenic enzymes in mammary glands and livers of lactating rats
Biochem J (1983) 216 (2): 515-518.
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M R Grigor, K R Gain; The effect of starvation and refeeding on lipogenic enzymes in mammary glands and livers of lactating rats. Biochem J 15 November 1983; 216 (2): 515–518. doi: https://doi.org/10.1042/bj2160515
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