Metabolic acidosis stimulates the rate of glutamine release from muscle, and this in turn is used by the kidney in acid-base balance. NH4Cl, HCl or diabetic ketoacidosis increases the maximum activity of glutamine synthetase in skeletal muscle. Starvation and administration of adrenal steroids also increase the activity of the enzyme in muscle.
Research Article|November 15 1983
Glutamine synthetase activity of muscle in acidosis
Biochem J (1983) 216 (2): 523-525.
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P A King, L Goldstein, E A Newsholme; Glutamine synthetase activity of muscle in acidosis. Biochem J 15 November 1983; 216 (2): 523–525. doi: https://doi.org/10.1042/bj2160523
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