An actinomycin D molecule bound to DNA sometimes stops the synthesis of RNA by Escherichia coli RNA polymerase. However, quite often, the bound antibiotic is released before the RNA polymerase detaches from the template DNA, so that the enzyme can resume, without interruption, the synthesis of the RNA chain.
Research Article|September 01 1985
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P A Flamée; The action of actinomycin D on the transcription of T7 coliphage DNA by Escherichia coli RNA polymerase. Biochem J 1 September 1985; 230 (2): 557–560. doi: https://doi.org/10.1042/bj2300557
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