The ability of nucleoside permeants to accelerate the efflux of uridine from human erythrocytes has been compared. In contrast to uridine, 2-chloroadenosine acted as a trans-inhibitor of uridine efflux from fresh human erythrocytes, and adenosine had little effect. These results are consistent with the lower maximum velocity for influx of 2-chloroadenosine and adenosine as compared with uridine and demonstrate that trans acceleration experiments do not discriminate between transported and non-transported permeants for the human erythrocyte nucleoside carrier.
Research Article|January 01 1986
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S M Jarvis; Trans-stimulation and trans-inhibition of uridine efflux from human erythrocytes by permeant nucleosides. Biochem J 1 January 1986; 233 (1): 295–297. doi: https://doi.org/10.1042/bj2330295
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