Accumulating evidence suggests that the increase in cytosolic Ca2+ induced by receptor agonists is mediated by inositol 1,4,5-trisphosphate, a product of phospholipase C-mediated breakdown of phosphatidylinositol 4,5-bisphosphate. The present study employs inositol tris[32P]phosphate to demonstrate a specific receptor binding site in a microsomal fraction of rat liver.
Research Article|February 01 1986
Binding of inositol trisphosphate by a liver microsomal fraction
Biochem J (1986) 233 (3): 929-932.
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A Spät, A Fabiato, R P Rubin; Binding of inositol trisphosphate by a liver microsomal fraction. Biochem J 1 February 1986; 233 (3): 929–932. doi: https://doi.org/10.1042/bj2330929
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