The activity of pyruvate dehydrogenase kinase in extracts of mitochondria from rat hepatocytes cultured for 21 h in medium 199 was increased 2.5-fold by the presence of 55 nM-glucagon and 1 mM-sodium n-octanoate in the culture medium. The change was comparable with that induced in vivo by 48 h starvation. The potential contribution of branched-chain complex to estimates of PDH-complex activity in rat liver mitochondria has been defined.
Research Article|February 15 1986
Modulation of pyruvate dehydrogenase kinase activity in cultured hepatocytes by glucagon and n-octanoate
Biochem J (1986) 234 (1): 233-236.
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H R Fatania, T C Vary, P J Randle; Modulation of pyruvate dehydrogenase kinase activity in cultured hepatocytes by glucagon and n-octanoate. Biochem J 15 February 1986; 234 (1): 233–236. doi: https://doi.org/10.1042/bj2340233
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