The primary structure of the cartilage matrix molecule chondrocalcin has been found to be identical with that of the C-propeptide of type II procollagen by comparing sequence analyses of the N-terminal regions and of tryptic peptides derived from chondrocalcin. This implies that in type II collagen the C-propeptide of type II collagen is employed not only in the assembly of the triple helix of type II collagen, as demonstrated previously, but in calcifying cartilage it may also be involved in those events leading to cartilage calcification, as earlier indicated.
Research Article|August 01 1986
Chondrocalcin is identical with the C-propeptide of type II procollagen
M Van der Rest;
L C Rosenberg; ;
Biochem J (1986) 237 (3): 923-925.
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M Van der Rest, L C Rosenberg, B R Olsen, A R Poole; Chondrocalcin is identical with the C-propeptide of type II procollagen. Biochem J 1 August 1986; 237 (3): 923–925. doi: https://doi.org/10.1042/bj2370923
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