1. The erythrocyte membrane acetylcholinesterase activity is significantly (P less than 0.001) decreased in insulin-dependent diabetes mellitus. 2. The activity is negatively correlated (r = -0.97) with the fasting blood glucose level. 3. Insulin treatment restores the activity to normal. 4. The Km of the enzyme for acetylthiocholine iodide was unchanged; however, the Vmax. was decreased, suggesting a decrease in the number of active enzyme molecules in diabetes.
Research Article|May 01 1989
Erythrocyte membrane acetylcholinesterase in type 1 (insulin-dependent) diabetes mellitus
Biochem J (1989) 259 (3): 897-899.
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M Suhail, S I Rizvi; Erythrocyte membrane acetylcholinesterase in type 1 (insulin-dependent) diabetes mellitus. Biochem J 1 May 1989; 259 (3): 897–899. doi: https://doi.org/10.1042/bj2590897
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