The effect of alpha 2-macroglobulin, one of the major antiproteinases in the plasma of vertebrates, on the action of the aspartic proteinases chymosin, cathepsin D and cathepsin E towards peptide and protein substrates at pH 6.2 was examined. Activities towards protein substrates were blocked, thus demonstrating that alpha 2-macroglobulin can inhibit aspartic proteinases, in addition to serine proteinases, cysteine proteinases and metalloproteinases.
Research Article|May 01 1989
Inhibition of aspartic proteinases by α2-macroglobulin
D J Thomas;
A D Richards;
Biochem J (1989) 259 (3): 905-907.
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D J Thomas, A D Richards, J Kay; Inhibition of aspartic proteinases by α2-macroglobulin. Biochem J 1 May 1989; 259 (3): 905–907. doi: https://doi.org/10.1042/bj2590905
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