Fasted (48 h) rats were killed at 0, 2, 4, 6, 8, 12, 16, 20 and 24 h after they were refed on a high-carbohydrate diet. An increase in the maximal activity and quantity of cystolic acetyl-CoA carboxylase was found in liver of refed rats after a lag time of about 8 h. The increased quantity of cytosolic enzyme was attributable primarily to mobilization of mitochondrial storage forms and not to substantial increase in the rate of synthesis of acetyl-CoA carboxylase.
Mitochondrial acetyl-CoA carboxylase. Time course of mobilization/activation in liver of refed rats
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C R Roman-Lopez, B J Shriver, C R Joseph, J B Allred; Mitochondrial acetyl-CoA carboxylase. Time course of mobilization/activation in liver of refed rats. Biochem J 15 June 1989; 260 (3): 927–930. doi: https://doi.org/10.1042/bj2600927
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