The [32P]PIP2/[32P]PA and the [32P]PIP/[32P]PA relationships were demonstrated to be remarkably similar after stimulation of [32P]Pi-prelabelled platelets for 90 s with various combinations and concentrations of agonists and inhibitors. Thus the activity of the PI and PIP kinases with the corresponding phosphomonoesterases may be tightly controlled during receptor-mediated platelet stimulation involving phospholipase C activation.
Evidence for tight metabolic control of the receptor-activated polyphosphoinositide cycle in human platelets
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V M Steen, O B Tysnes, H Holmsen; Evidence for tight metabolic control of the receptor-activated polyphosphoinositide cycle in human platelets. Biochem J 15 October 1989; 263 (2): 621–624. doi: https://doi.org/10.1042/bj2630621
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