In mediating the entry of adenosine into mouse erythrocytes and mouse leukaemia L1210 cells, nucleoside transport systems were stereoselective, showing a marked preference for the D-enantiomer of adenosine (D-Ado). Inward zero-trans fluxes of the mirror-image isomer, L-adenosine (L-Ado), in those cells were slow relative to those of D-Ado. Contributing to L-Ado fluxes in both cell types were (i) a transporter-mediated process of high nitrobenzylthioinosine-sensitivity and (ii) simple diffusion.
Research Article|November 01 1989
Enantiomeric selectivity of adenosine transport systems in mouse erythrocytes and L1210 cells
W P Gati;
Biochem J (1989) 263 (3): 957-960.
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W P Gati, L Dagnino, A R P Paterson; Enantiomeric selectivity of adenosine transport systems in mouse erythrocytes and L1210 cells. Biochem J 1 November 1989; 263 (3): 957–960. doi: https://doi.org/10.1042/bj2630957
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