Changes in the amounts and functions of G-proteins have been reported in diabetic rats. We determined the Gi/Gs ratio of adipocyte plasma membranes in six insulinopenic diabetic patients and matched controls by immunoblotting with antisera against synthetic peptides corresponding to regions of G-proteins. No consistent changes in the Gi/Gs ratio were observed. It is still possible that the functional status of the G-proteins may be altered in diabetes.
Research Article|November 15 1989
Adipocyte plasma-membrane Gi and Gs in insulinopenic diabetic patients
J J Ohisalo;
J J Ohisalo
*Department of Medical Chemistry, University of Helsinki, Siltavuorenpenger 10 A, SF-00170 Helsinki, Finland
†III Department of Medicine, University Central Hospital, SF-00290 Helsinki, Finland
‡Molecular Pharmacology Group, Department of Biochemistry, University of Glasgow, Glasgow G12 8QQ, Scotland, U.K.
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H L Vikman;
M D Houslay;
Biochem J (1989) 264 (1): 289-292.
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J J Ohisalo, H L Vikman, S Ranta, M D Houslay, G Milligan; Adipocyte plasma-membrane Gi and Gs in insulinopenic diabetic patients. Biochem J 15 November 1989; 264 (1): 289–292. doi: https://doi.org/10.1042/bj2640289
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