By SDS/PAGE analysis we have observed that human synovial cell monolayers secrete a prominent 39 kDa protein which could not be detected in skin and lung fibroblasts. This protein was purified to homogeneity by heparin-Sepharose chromatography and reverse-phase h.p.l.c. The N-terminal sequence was found to be almost identical to that of a recently described bovine protein detected in the mammary secretions during the involutionary phase of the lactational cycle. Characterization of this 39 kDa protein may provide a useful marker for classification of connective tissue cells.
Research Article| July 01 1990
Human synovial cells secrete a 39 kDa protein similar to a bovine mammary protein expressed during the non-lactating period
Biochem J (1990) 269 (1): 265–268.
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P Nyirkos, E E Golds; Human synovial cells secrete a 39 kDa protein similar to a bovine mammary protein expressed during the non-lactating period. Biochem J 1 July 1990; 269 (1): 265–268. doi: https://doi.org/10.1042/bj2690265
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