Voltage-dependent K+ channels (RBK1, RBK2 and RGK5) were co-expressed in Xenopus oocytes with 5-hydroxytryptamine (5-HT2) receptors. K+ currents measured 2-4 days later were inhibited by 5-HT (100 nM-10 microM, 20-30 s application) by up to 90%. The effect of 5-HT was mimicked by intracellular injection of Ins(1,4,5)P3. Increasing the Ca2+ concentration at the inner surface of excised membrane patches did not decrease the K+ current.
Transmitter regulation of voltage-dependent K+ channels expressed in Xenopus oocytes
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M P Kavanaugh, M J Christie, P B Osborne, A E Busch, K Z Shen, Y N Wu, P H Seeburg, J P Adelman, R A North; Transmitter regulation of voltage-dependent K+ channels expressed in Xenopus oocytes. Biochem J 1 August 1991; 277 (3): 899–902. doi: https://doi.org/10.1042/bj2770899
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