Rat surfactant protein D (SP-D) was shown to enhance the production of oxygen radicals by rat alveolar macrophages. This enhancement, which was determined by a lucigenin-dependent chemiluminescence assay, was maximal after 18 min at an SP-D concentration of 0.2 micrograms/ml. Surfactant lipids did not influence the stimulation of alveolar macrophages by SP-D, whereas the oxygen-radical production of these cells induced by surfactant protein A was inhibited by the lipids in a concentration-dependent manner.
Rat surfactant protein D enhances the production of oxygen radicals by rat alveolar macrophages
- Views Icon Views
- PDF LinkPDF
- Share Icon Share
- Cite Icon Cite
J F Van Iwaarden, H Shimizu, P H M Van Golde, D R Voelker, L M G Van Golde; Rat surfactant protein D enhances the production of oxygen radicals by rat alveolar macrophages. Biochem J 15 August 1992; 286 (1): 5–8. doi: https://doi.org/10.1042/bj2860005
Download citation file: