1,1,1-Trichloroethane (TCE) is a widely used industrial solvent of low acute toxicity. It is slowly oxidized to trichloroethanol and trichloroacetic acid by cytochrome P-450-dependent mono-oxygenases. Increased inhalative uptake by rats under hypoxia and spin-trapping experiments indicate that TCE is also reductively metabolized to a radical intermediate. Acetylene is formed as a metabolite, suggesting transfer of an additional electron to form the corresponding carbene. Hypoxia and induction of mixed-function mono-oxygenases accelerate the formation of acetylene. Experiments performed in vitro with rat liver microsomal fractions yield analogous results.
Research Article| September 01 1992
Acetylene, a mammalian metabolite of 1,1,1-trichloroethane
J L Poyer;
Biochem J (1992) 286 (2): 353–356.
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H Dürk, J L Poyer, C Klessen, H Frank; Acetylene, a mammalian metabolite of 1,1,1-trichloroethane. Biochem J 1 September 1992; 286 (2): 353–356. doi: https://doi.org/10.1042/bj2860353
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