A novel protein [designated protein tyrosine phosphatase-like protein (PTPLP)] which is distantly related to receptor-type protein tyrosine phosphatases (PTPases) was cloned from a rat pheochromocytoma cell line. The PTPLP was detected exclusively in the brain. Overexpression of the PTPLP decreased the basal PTPase activity of COS-7 cells for Raytide. These results suggest that PTPLP may function as a negative regulator of PTPases in neuronal tissues.
Cloning and expression of protein tyrosine phosphatase-like protein derived from a rat pheochromocytoma cell line
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Y Kambayashi, K Takahashi, S Bardhan, T Inagami; Cloning and expression of protein tyrosine phosphatase-like protein derived from a rat pheochromocytoma cell line. Biochem J 1 March 1995; 306 (2): 331–335. doi: https://doi.org/10.1042/bj3060331
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