The structure and organization of the human Theta-class glutathione S-transferase (GST) genes have been determined. GSTT1 and GSTT2 are separated by approx. 50 kb. They have a similar structure, being composed of five exons with identical exon/intron boundaries. GSTT1 is 8.1 kb in length, while GSTT2 is only 3.7 kb. The GSTT2 gene lies head-to-head with a gene encoding d-dopachrome tautomerase (DDCT), which extends over 8.5 kb and contains four exons. The sequence between GSTT2 and DDCT may contain a bidirectional promoter. The GSTT2 and DDCT genes have been duplicated in an inverted repeat. Sequence analysis of the duplicated GSTT2 gene has identified an exon 2/intron 2 splice site abnormality and a premature translation stop signal at codon 196. These changes suggest that the duplicate gene is a pseudogene, and it has been named GSTT2P.
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September 1998
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Research Article|
September 15 1998
Structure and organization of the human Theta-class glutathione S-transferase and d-dopachrome tautomerase gene complex
Marjorie COGGAN;
Marjorie COGGAN
1Molecular Genetics Group, John Curtin School of Medical Research, Australian National University, P.O. Box 334, Canberra, ACT 2601, Australia
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Lel WHITBREAD;
Lel WHITBREAD
1Molecular Genetics Group, John Curtin School of Medical Research, Australian National University, P.O. Box 334, Canberra, ACT 2601, Australia
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Angela WHITTINGTON;
Angela WHITTINGTON
1Molecular Genetics Group, John Curtin School of Medical Research, Australian National University, P.O. Box 334, Canberra, ACT 2601, Australia
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Philip BOARD
Philip BOARD
1
1Molecular Genetics Group, John Curtin School of Medical Research, Australian National University, P.O. Box 334, Canberra, ACT 2601, Australia
1To whom correspondence should be addressed (e-mail Philip.Board@anu.edu.au).
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Publisher: Portland Press Ltd
Received:
April 14 1998
Revision Received:
June 18 1998
Accepted:
July 08 1998
Online ISSN: 1470-8728
Print ISSN: 0264-6021
The Biochemical Society, London © 1998
1998
Biochem J (1998) 334 (3): 617–623.
Article history
Received:
April 14 1998
Revision Received:
June 18 1998
Accepted:
July 08 1998
Citation
Marjorie COGGAN, Lel WHITBREAD, Angela WHITTINGTON, Philip BOARD; Structure and organization of the human Theta-class glutathione S-transferase and d-dopachrome tautomerase gene complex. Biochem J 15 September 1998; 334 (3): 617–623. doi: https://doi.org/10.1042/bj3340617
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