Abbreviations used: 3-MA, 3-methyladenine; 4E-BP1, eIF4E-binding protein 1; BCAA, branched-chain amino acids; CHO, Chinese-hamster ovary; CHX, cycloheximide; D-PBS, Dulbecco's PBS; eIF, eukaryotic initiation factor; GCN2, general control of amino acid biosynthesis, non-derepressing, 2; GSK3, glycogen synthase kinase 3; GST, glutathione S-transferase; hsp, heat-shock protein; JNK, c-Jun N-terminal kinase; MAP kinase, mitogen-activated protein kinase; MAPKAPK-2, MAP kinase-activated kinase-2; mTOR, mammalian target of rapamycin; PKB, protein kinase B; rp, ribosomal protein; S6K, rp S6 kinase; TOP, tract of pyrimidines.

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Author notes

1

Present address: Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, U.S.A.