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IQGAP1 is a scaffold protein for both the RAS/MAP kinase and PI 3-kinase signalling pathways, as shown on the right. Its WW domain, modelled on the left, has anti-tumour activity when engineered as a cell-penetrating peptide. The study by Bardwell and colleagues (pp. 729–750) shows that the catalytic subunit of PI 3-kinase, a known driver oncogene, is a direct binding partner of the WW domain, which could help explain its anti-tumour properties. The image was provided by Lee Bardwell.
In this Issue
The WW domain of IQGAP1 binds directly to the p110α catalytic subunit of PI 3-kinase
A. Jane Bardwell; Madhuri Paul; Kiku C. Yoneda; María D. Andrade-Ludeña; Oanh T. Nguyen; David A. Fruman; Lee Bardwell
Biochem J (2023) 480 (10): 729–750.
Correction: Novel insights into the recognition of acetylated histone H4 tail by the TRIM24 PHD-Bromo module
Biochem J (2023) 480 (10): 751.