Skip Nav Destination

Issues

Select Decade

Select Year

Issue

Volume 412, Issue 2

June 2008

All Issues

Cover Image

Cover Image
Front Matter
Table of Contents
Editorial Board

ISSN 0264-6021

EISSN 1470-8728

In this Issue

Review articles
Accelerated Publications
Research articles
Commentaries
Reader's Choice

Review articles

The TSC1–TSC2 complex: a molecular switchboard controlling cell growth

Jingxiang Huang; Brendan D. Manning

Biochem J (2008) 412 (2): 179–190.

Abstract

View Articletitled, The TSC1–TSC2 complex: a molecular switchboard controlling cell growth

Open the PDF for in another window

Huntington's disease: from pathology and genetics to potential therapies

Sara Imarisio; Jenny Carmichael; Viktor Korolchuk; Chien-Wen Chen; Shinji Saiki; Claudia Rose; Gauri Krishna; Janet E. Davies; Evangelia Ttofi; Benjamin R. Underwood; David C. Rubinsztein

Biochem J (2008) 412 (2): 191–209.

Abstract

View Articletitled, Huntington's disease: from pathology and genetics to potential therapies

Open the PDF for in another window

Accelerated Publications

Important role of the LKB1–AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice

Xu Huang; Stephan Wullschleger; Natalia Shpiro; Victoria A. McGuire; Kei Sakamoto; Yvonne L. Woods; Wendy Mcburnie; Stewart Fleming; Dario R. Alessi

Biochem J (2008) 412 (2): 211–221.

Abstract

View Articletitled, Important role of the LKB1–AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice

Supplementary data

Open the PDF for in another window

Research articles

Nitric oxide-mediated modulation of calcium/calmodulin-dependent protein kinase II

Tao Song; Naoya Hatano; Toshie Kambe; Yoshiaki Miyamoto; Hideshi Ihara; Hideyuki Yamamoto; Katsuyoshi Sugimoto; Kodai Kume; Fuminori Yamaguchi; Masaaki Tokuda; Yasuo Watanabe

Biochem J (2008) 412 (2): 223–231.

Abstract

View Articletitled, Nitric oxide-mediated modulation of calcium/calmodulin-dependent protein kinase II

Supplementary data

Open the PDF for in another window

Monitoring conformational changes during the catalytic cycle of OpuAA, the ATPase subunit of the ABC transporter OpuA from Bacillus subtilis

Carsten Horn; Stefan Jenewein; Britta Tschapek; Werner Bouschen; Sabine Metzger; Erhard Bremer; Lutz Schmitt

Biochem J (2008) 412 (2): 233–244.

Abstract

View Articletitled, Monitoring conformational changes during the catalytic cycle of OpuAA, the ATPase subunit of the ABC transporter OpuA from Bacillus subtilis

Supplementary data

Open the PDF for in another window

CXCR2 chemokine receptor antagonism enhances DOP opioid receptor function via allosteric regulation of the CXCR2–DOP receptor heterodimer

Geraldine Parenty; Shirley Appelbe; Graeme Milligan

Biochem J (2008) 412 (2): 245–256.

Abstract

View Articletitled, CXCR2 chemokine receptor antagonism enhances DOP opioid receptor function via allosteric regulation of the CXCR2–DOP receptor heterodimer

Open the PDF for in another window

The crystal structure of peroxymyoglobin generated through cryoradiolytic reduction of myoglobin compound III during data collection

Hans-Petter Hersleth; Ya-Wen Hsiao; Ulf Ryde; Carl Henrik Görbitz; K. Kristoffer Andersson

Biochem J (2008) 412 (2): 257–264.

Abstract

View Articletitled, The crystal structure of peroxymyoglobin generated through cryoradiolytic reduction of myoglobin compound III during data collection

Open the PDF for in another window

Cep57, a multidomain protein with unique microtubule and centrosomal localization domains

Ko Momotani; Alexander S. Khromov; Tsuyoshi Miyake; P. Todd Stukenberg; Avril V. Somlyo

Biochem J (2008) 412 (2): 265–273.

Abstract

View Articletitled, Cep57, a multidomain protein with unique microtubule and centrosomal localization domains

Open the PDF for in another window

Diverse roles for chloroplast stromal and thylakoid-bound ascorbate peroxidases in plant stress responses

Saijaliisa Kangasjärvi; Anna Lepistö; Kati Hännikäinen; Mirva Piippo; Eeva-Maria Luomala; Eva-Mari Aro; Eevi Rintamäki

Biochem J (2008) 412 (2): 275–285.

Abstract

View Articletitled, Diverse roles for chloroplast stromal and thylakoid-bound ascorbate peroxidases in plant stress responses

Supplementary data

Open the PDF for in another window

Negative-feedback regulation of FGF signalling by DUSP6/MKP-3 is driven by ERK1/2 and mediated by Ets factor binding to a conserved site within the DUSP6/MKP-3 gene promoter

Maria Ekerot; Marios P. Stavridis; Laurent Delavaine; Michael P. Mitchell; Christopher Staples; David M. Owens; Iain D. Keenan; Robin J. Dickinson; Kate G. Storey; Stephen M. Keyse

Biochem J (2008) 412 (2): 287–298.

Abstract

View Articletitled, Negative-feedback regulation of FGF signalling by DUSP6/MKP-3 is driven by ERK1/2 and mediated by Ets factor binding to a conserved site within the DUSP6/MKP-3 gene promoter

Open the PDF for in another window

The Rb/E2F pathway and Ras activation regulate RecQ helicase gene expression

Yongqing Liu; Shahenda El-Naggar; Brian Clem; Jason Chesney; Douglas C. Dean

Biochem J (2008) 412 (2): 299–306.

Abstract

View Articletitled, The Rb/E2F pathway and Ras activation regulate RecQ helicase gene expression

Supplementary data

Open the PDF for in another window

Splice-switching efficiency and specificity for oligonucleotides with locked nucleic acid monomers

Peter Guterstam; Maria Lindgren; Henrik Johansson; Ulf Tedebark; Jesper Wengel; Samir El Andaloussi; Ülo Langel

Biochem J (2008) 412 (2): 307–313.

Abstract

View Articletitled, Splice-switching efficiency and specificity for oligonucleotides with locked nucleic acid monomers

Supplementary data

Open the PDF for in another window

The intact CFTR protein mediates ATPase rather than adenylate kinase activity

Mohabir Ramjeesingh; Francisca Ugwu; Fiona L. L. Stratford; Ling-Jun Huan; Canhui Li; Christine E. Bear

Biochem J (2008) 412 (2): 315–321.

Abstract

View Articletitled, The intact CFTR protein mediates ATPase rather than adenylate kinase activity

Open the PDF for in another window

Critical role for cross-linking of trimeric lectin domains of surfactant protein D in antiviral activity against influenza A virus

Tesfaldet Tecle; Mitchell R. White; Grith Sorensen; Donald Gantz; Nilgun Kacak; Uffe Holmskov; Kelly Smith; Erika C. Crouch; Kevan L. Hartshorn

Biochem J (2008) 412 (2): 323–329.

Abstract

View Articletitled, Critical role for cross-linking of trimeric lectin domains of surfactant protein D in antiviral activity against influenza A virus

Open the PDF for in another window

The tumour suppressor PTEN mediates a negative regulation of the E3 ubiquitin-protein ligase Nedd4

Younghee Ahn; Chae Young Hwang; Seung-Rock Lee; Ki-Sun Kwon; Cheolju Lee

Biochem J (2008) 412 (2): 331–338.

Abstract

View Articletitled, The tumour suppressor PTEN mediates a negative regulation of the E3 ubiquitin-protein ligase Nedd4

Supplementary data

Open the PDF for in another window

Proximal mutations at the type 1 copper site of CotA laccase: spectroscopic, redox, kinetic and structural characterization of I494A and L386A mutants

Paulo Durão; Zhenjia Chen; Catarina S. Silva; Cláudio M. Soares; Manuela M. Pereira; Smilja Todorovic; Peter Hildebrandt; Isabel Bento; Peter F. Lindley; Lígia O. Martins

Biochem J (2008) 412 (2): 339–346.

Abstract

View Articletitled, Proximal mutations at the type 1 copper site of CotA laccase: spectroscopic, redox, kinetic and structural characterization of I494A and L386A mutants

Supplementary data

Open the PDF for in another window

Analysis of endogenous Bax complexes during apoptosis using blue native PAGE: implications for Bax activation and oligomerization

Anthony J. Valentijn; John-Paul Upton; Andrew P. Gilmore

Biochem J (2008) 412 (2): 347–357.

Abstract

View Articletitled, Analysis of endogenous Bax complexes during apoptosis using blue native PAGE: implications for Bax activation and oligomerization

Open the PDF for in another window

Inhibition of the interaction between protein phosphatase 1 glycogen-targeting subunit and glycogen phosphorylase increases glycogen synthesis in primary rat hepatocytes

Darya Zibrova; Rolf Grempler; Rüdiger Streicher; Stefan G. Kauschke

Biochem J (2008) 412 (2): 359–366.

Abstract

View Articletitled, Inhibition of the interaction between protein phosphatase 1 glycogen-targeting subunit and glycogen phosphorylase increases glycogen synthesis in primary rat hepatocytes

Open the PDF for in another window

In vivo quantitative relationship between plastid division proteins FtsZ1 and FtsZ2 and identification of ARC6 and ARC3 in a native FtsZ complex

Rosemary S. Mcandrew; Bradley J. S. C. Olson; Deena K. Kadirjan-Kalbach; Cecilia L. Chi-Ham; Stanislav Vitha; John E. Froehlich; Katherine W. Osteryoung

Biochem J (2008) 412 (2): 367–378.

Abstract

View Articletitled, In vivo quantitative relationship between plastid division proteins FtsZ1 and FtsZ2 and identification of ARC6 and ARC3 in a native FtsZ complex

Supplementary data

Open the PDF for in another window

Dihydropteroate synthase from Streptococcus pneumoniae: structure, ligand recognition and mechanism of sulfonamide resistance

Colin Levy; David Minnis; Jeremy P. Derrick

Biochem J (2008) 412 (2): 379–388.

Abstract

View Articletitled, Dihydropteroate synthase from Streptococcus pneumoniae: structure, ligand recognition and mechanism of sulfonamide resistance

Open the PDF for in another window

Conserved amphiphilic feature is essential for periplasmic chaperone HdeA to support acid resistance in enteric bacteria

Ye E. Wu; Weizhe Hong; Chong Liu; Lingqing Zhang; Zengyi Chang

Biochem J (2008) 412 (2): 389–397.

Abstract

View Articletitled, Conserved amphiphilic feature is essential for periplasmic chaperone HdeA to support acid resistance in enteric bacteria

Open the PDF for in another window

Commentaries

Cancer therapy: staying current with AMPK

David A. Fruman; Aimee L. Edinger

Biochem J (2008) 412 (2): e3–e5.

Abstract

View Articletitled, Cancer therapy: staying current with AMPK

Open the PDF for in another window

Opioid and chemokine receptor heterodimers: arranged marriages or dangerous liaisons?

Terence E. Hébert

Biochem J (2008) 412 (2): e7–e9.

Abstract

View Articletitled, Opioid and chemokine receptor heterodimers: arranged marriages or dangerous liaisons?

Open the PDF for in another window

Reader's Choice

S-Nitrosation and thiol switching in the mitochondrion: a new paradigm for cardioprotection in ischaemic preconditioning

Bradford G. Hill; Victor M. Darley-Usmar

Biochem J (2008) 412 (2): e11–e13.

Abstract

View Articletitled, S-Nitrosation and thiol switching in the mitochondrion: a new paradigm for cardioprotection in ischaemic preconditioning

Open the PDF for in another window

AMPK, MAPK and Bax in the heart: some questions answered

Vilmante Borutaite

Biochem J (2008) 412 (2): e15–e16.

Abstract

View Articletitled, AMPK, MAPK and Bax in the heart: some questions answered

Open the PDF for in another window

Submit your work

Email alerts

Accepted Manuscript Alert

Latest Completed Issue Alert

Latest
Most Read
Most Cited

Macromolecular crowding and bicarbonate enhance the hydrogen peroxide-induced inactivation of glyceraldehyde-3-phosphate dehydrogenase

Editorial Note: Camelid single-domain antibodies raised by DNA immunization are potent inhibitors of EGFR signaling

Biochemical basis and therapeutic potential of mitochondrial uncoupling in cardiometabolic syndrome

Tweaking the redox properties of PpcA from Geobacter metallireducens with protein engineering

Opposed regulation of endoplasmic reticulum retention under stress by ERp44 and PDIA6

Review articles

The TSC1–TSC2 complex: a molecular switchboard controlling cell growth

Huntington's disease: from pathology and genetics to potential therapies

Accelerated Publications

Important role of the LKB1–AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice

Research articles

Nitric oxide-mediated modulation of calcium/calmodulin-dependent protein kinase II

Monitoring conformational changes during the catalytic cycle of OpuAA, the ATPase subunit of the ABC transporter OpuA from Bacillus subtilis

CXCR2 chemokine receptor antagonism enhances DOP opioid receptor function via allosteric regulation of the CXCR2–DOP receptor heterodimer

The crystal structure of peroxymyoglobin generated through cryoradiolytic reduction of myoglobin compound III during data collection

Cep57, a multidomain protein with unique microtubule and centrosomal localization domains

Diverse roles for chloroplast stromal and thylakoid-bound ascorbate peroxidases in plant stress responses

Negative-feedback regulation of FGF signalling by DUSP6/MKP-3 is driven by ERK1/2 and mediated by Ets factor binding to a conserved site within the DUSP6/MKP-3 gene promoter

The Rb/E2F pathway and Ras activation regulate RecQ helicase gene expression

Splice-switching efficiency and specificity for oligonucleotides with locked nucleic acid monomers

The intact CFTR protein mediates ATPase rather than adenylate kinase activity

Critical role for cross-linking of trimeric lectin domains of surfactant protein D in antiviral activity against influenza A virus

The tumour suppressor PTEN mediates a negative regulation of the E3 ubiquitin-protein ligase Nedd4

Proximal mutations at the type 1 copper site of CotA laccase: spectroscopic, redox, kinetic and structural characterization of I494A and L386A mutants

Analysis of endogenous Bax complexes during apoptosis using blue native PAGE: implications for Bax activation and oligomerization

Inhibition of the interaction between protein phosphatase 1 glycogen-targeting subunit and glycogen phosphorylase increases glycogen synthesis in primary rat hepatocytes

In vivo quantitative relationship between plastid division proteins FtsZ1 and FtsZ2 and identification of ARC6 and ARC3 in a native FtsZ complex

Dihydropteroate synthase from Streptococcus pneumoniae: structure, ligand recognition and mechanism of sulfonamide resistance

Conserved amphiphilic feature is essential for periplasmic chaperone HdeA to support acid resistance in enteric bacteria

Commentaries

Cancer therapy: staying current with AMPK

Opioid and chemokine receptor heterodimers: arranged marriages or dangerous liaisons?

Reader's Choice

S-Nitrosation and thiol switching in the mitochondrion: a new paradigm for cardioprotection in ischaemic preconditioning

AMPK, MAPK and Bax in the heart: some questions answered

Email alerts

CONNECT

EXPLORE

Issues

Cover Image

Review articles

Accelerated Publications

Research articles

Commentaries

Reader's Choice

Email alerts

CONNECT

EXPLORE

This Feature Is Available To Subscribers Only