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Volume 425, Issue 1

January 2010

All Issues

Cover Image

Cover Image
Front Matter
Table of Contents
Editorial Board

ISSN 0264-6021

EISSN 1470-8728

In this Issue

Review articles
Research articles
Commentaries

Review articles

‘Unknown’ proteins and ‘orphan’ enzymes: the missing half of the engineering parts list – and how to find it

Andrew D. Hanson; Anne Pribat; Jeffrey C. Waller; Valérie de Crécy-Lagard

Biochem J (2010) 425 (1): 1–11.

Abstract

View Articletitled, ‘Unknown’ proteins and ‘orphan’ enzymes: the missing half of the engineering parts list – and how to find it

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Molecular mechanisms of metabolic regulation by insulin in Drosophila

Aurelio A. Teleman

Biochem J (2010) 425 (1): 13–26.

Abstract

View Articletitled, Molecular mechanisms of metabolic regulation by insulin in Drosophila

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Breaking the code: Ca²⁺ sensors in plant signalling

Thomas A. DeFalco; Kyle W. Bender; Wayne A. Snedden

Biochem J (2010) 425 (1): 27–40.

Abstract

View Articletitled, Breaking the code: Ca2+ sensors in plant signalling

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Transcriptional and post-translational regulation of adiponectin

Meilian Liu; Feng Liu

Biochem J (2010) 425 (1): 41–52.

Abstract

View Articletitled, Transcriptional and post-translational regulation of adiponectin

Supplementary data

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Guidelines for the effective use of chemical inhibitors of protein function to understand their roles in cell regulation

Philip Cohen

Biochem J (2010) 425 (1): 53–54.

Abstract

View Articletitled, Guidelines for the effective use of chemical inhibitors of protein function to understand their roles in cell regulation

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Research articles

An allosteric transition trapped in an intermediate state of a new kinesin–inhibitor complex

Hung Yi Kristal Kaan; Venkatasubramanian Ulaganathan; David D. Hackney; Frank Kozielski

Biochem J (2010) 425 (1): 55–61.

Abstract

View Articletitled, An allosteric transition trapped in an intermediate state of a new kinesin–inhibitor complex

Supplementary data

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Targeting of inositol 1,4,5-trisphosphate receptor to the endoplasmic reticulum by its first transmembrane domain

Evangelia Pantazaka; Colin W. Taylor

Biochem J (2010) 425 (1): 61–74.

Abstract

View Articletitled, Targeting of inositol 1,4,5-trisphosphate receptor to the endoplasmic reticulum by its first transmembrane domain

Supplementary data

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Brd2 disruption in mice causes severe obesity without Type 2 diabetes

Fangnian Wang; Hongsheng Liu; Wanda P. Blanton; Anna Belkina; Nathan K. Lebrasseur; Gerald V. Denis

Biochem J (2010) 425 (1): 71–85.

Abstract

View Articletitled, Brd2 disruption in mice causes severe obesity without Type 2 diabetes

Supplementary data

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Structural and functional analysis of the intrinsic inhibitor subunit ϵ of F₁-ATPase from photosynthetic organisms

Hiromasa Yagi; Hiroki Konno; Tomoe Murakami-Fuse; Atsuko Isu; Tomotaka Oroguchi; Hideo Akutsu; Mitsunori Ikeguchi; Toru Hisabori

Biochem J (2010) 425 (1): 85–98.

Abstract

View Articletitled, Structural and functional analysis of the intrinsic inhibitor subunit ϵ of F1-ATPase from photosynthetic organisms

Supplementary data

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SCG10-like protein (SCLIP) is a STAT3-interacting protein involved in maintaining epithelial morphology in MCF-7 breast cancer cells

Dominic C. H. Ng; Cheh P. Lim; Bao H. Lin; Tong Zhang; Xinmin Cao

Biochem J (2010) 425 (1): 95–108.

Abstract

View Articletitled, SCG10-like protein (SCLIP) is a STAT3-interacting protein involved in maintaining epithelial morphology in MCF-7 breast cancer cells

Supplementary data

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PBX1 and MEIS1 up-regulate SOX3 gene expression by direct interaction with a consensus binding site within the basal promoter region

Marija Mojsin; Milena Stevanovic

Biochem J (2010) 425 (1): 107–116.

Abstract

View Articletitled, PBX1 and MEIS1 up-regulate SOX3 gene expression by direct interaction with a consensus binding site within the basal promoter region

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Positive contribution of ERdj5/JPDI to endoplasmic reticulum protein quality control in the salivary gland

Akira Hosoda; Mio Tokuda; Ryoko Akai; Kenji Kohno; Takao Iwawaki

Biochem J (2010) 425 (1): 117–128.

Abstract

View Articletitled, Positive contribution of ERdj5/JPDI to endoplasmic reticulum protein quality control in the salivary gland

Supplementary data

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Molecular identification of aspartate N-acetyltransferase and its mutation in hypoacetylaspartia

Elsa Wiame; Donatienne Tyteca; Nathalie Pierrot; François Collard; Mustapha Amyere; Gaëtane Noel; Jonathan Desmedt; Marie-Cécile Nassogne; Miikka Vikkula; Jean-Noël Octave; Marie-Françoise Vincent; Pierre J. Courtoy; Eugen Boltshauser; Emile van Schaftingen

Biochem J (2010) 425 (1): 127–139.

Abstract

View Articletitled, Molecular identification of aspartate N-acetyltransferase and its mutation in hypoacetylaspartia

Supplementary data

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Mitochondrial targeting of cyclosporin A enables selective inhibition of cyclophilin-D and enhanced cytoprotection after glucose and oxygen deprivation

Sylvanie Malouitre; Henry Dube; David Selwood; Martin Crompton

Biochem J (2010) 425 (1): 137–148.

Abstract

View Articletitled, Mitochondrial targeting of cyclosporin A enables selective inhibition of cyclophilin-D and enhanced cytoprotection after glucose and oxygen deprivation

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Comparison of the cellular and biochemical properties of Plasmodium falciparum choline and ethanolamine kinases

Blandine Alberge; Leila Gannoun-Zaki; Céline Bascunana; Christophe Tran van Ba; Henri Vial; Rachel Cerdan

Biochem J (2010) 425 (1): 149–163.

Abstract

View Articletitled, Comparison of the cellular and biochemical properties of Plasmodium falciparum choline and ethanolamine kinases

Supplementary data

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Role of phosphoinositides in STIM1 dynamics and store-operated calcium entry

Ciara M. Walsh; Michael Chvanov; Lee P. Haynes; Ole H. Petersen; Alexei V. Tepikin; Robert D. Burgoyne

Biochem J (2010) 425 (1): 159–168.

Abstract

View Articletitled, Role of phosphoinositides in STIM1 dynamics and store-operated calcium entry

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G-protein-coupled-receptor kinases mediate TNFα-induced NF-κB signalling via direct interaction with and phosphorylation of IκBα

Sonika Patial; Jiansong Luo; Katie J. Porter; Jeffrey L. Benovic; Narayanan Parameswaran

Biochem J (2010) 425 (1): 169–180.

Abstract

View Articletitled, G-protein-coupled-receptor kinases mediate TNFα-induced NF-κB signalling via direct interaction with and phosphorylation of IκBα

Supplementary data

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Reversible bleb formation in mast cells stimulated with antigen is Ca²⁺/calmodulin-dependent and bleb size is regulated by ARF6

Yuhki Yanase; Nicolas Carvou; Michael A. Frohman; Shamshad Cockcroft

Biochem J (2010) 425 (1): 179–193.

Abstract

View Articletitled, Reversible bleb formation in mast cells stimulated with antigen is Ca2+/calmodulin-dependent and bleb size is regulated by ARF6

Supplementary data

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A di-arginine motif contributes to the ER localization of the type I transmembrane ER oxidoreductase TMX4

Doris Roth; Emily Lynes; Jan Riemer; Henning G. Hansen; Nils Althaus; Thomas Simmen; Lars Ellgaard

Biochem J (2010) 425 (1): 195–208.

Abstract

View Articletitled, A di-arginine motif contributes to the ER localization of the type I transmembrane ER oxidoreductase TMX4

Supplementary data

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Chloroplast HCF101 is a scaffold protein for [4Fe-4S] cluster assembly

Serena Schwenkert; Daili J. A. Netz; Jeverson Frazzon; Antonio J. Pierik; Eckhard Bill; Jeferson Gross; Roland Lill; Jörg Meurer

Biochem J (2010) 425 (1): 207–218.

Abstract

View Articletitled, Chloroplast HCF101 is a scaffold protein for [4Fe-4S] cluster assembly

Supplementary data

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C/EBP transcription factors regulate SREBP1c gene expression during adipogenesis

Victoria A. Payne; Wo-Shing Au; Christopher E. Lowe; Shaikh M. Rahman; Jacob E. Friedman; Stephen O'Rahilly; Justin J. Rochford

Biochem J (2010) 425 (1): 215–224.

Abstract

View Articletitled, C/EBP transcription factors regulate SREBP1c gene expression during adipogenesis

Supplementary data

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Fas/CD95 down-regulation in lymphoma cells through acquired alkyllysophospholipid resistance: partial role of associated sphingomyelin deficiency

Wim J. van Blitterswijk; Jeffrey B. Klarenbeek; Arnold H. van der Luit; Maaike C. Alderliesten; Menno van Lummel; Marcel Verheij

Biochem J (2010) 425 (1): 225–236.

Abstract

View Articletitled, Fas/CD95 down-regulation in lymphoma cells through acquired alkyllysophospholipid resistance: partial role of associated sphingomyelin deficiency

Supplementary data

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Regulatory factors controlling transcription of Saccharomyces cerevisiae IXR1 by oxygen levels: a model of transcriptional adaptation from aerobiosis to hypoxia implicating ROX1 and IXR1 cross-regulation

Raquel Castro-Prego; Mónica Lamas-Maceiras; Pilar Soengas; Isabel Carneiro; Isabel González-Siso; M. Esperanza Cerdán

Biochem J (2010) 425 (1): 235–243.

Abstract

View Articletitled, Regulatory factors controlling transcription of Saccharomyces cerevisiae IXR1 by oxygen levels: a model of transcriptional adaptation from aerobiosis to hypoxia implicating ROX1 and IXR1 cross-regulation

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Identification of the key structural motifs involved in HspB8/HspB6–Bag3 interaction

Margit Fuchs; Dominic J. Poirier; Samuel J. Seguin; Herman Lambert; Serena Carra; Steve J. Charette; Jacques Landry

Biochem J (2010) 425 (1): 245–257.

Abstract

View Articletitled, Identification of the key structural motifs involved in HspB8/HspB6–Bag3 interaction

Supplementary data

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Role of the cysteine protease interpain A of Prevotella intermedia in breakdown and release of haem from haemoglobin

Dominic P. Byrne; Katarzyna Wawrzonek; Anna Jaworska; Andrew J. Birss; Jan Potempa; John W. Smalley

Biochem J (2010) 425 (1): 257–264.

Abstract

View Articletitled, Role of the cysteine protease interpain A of Prevotella intermedia in breakdown and release of haem from haemoglobin

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Coactosin-like protein functions as a stabilizing chaperone for 5-lipoxygenase: role of tryptophan 102

Julia Esser; Marija Rakonjac; Bettina Hofmann; Lutz Fischer; Patrick Provost; Gisbert Schneider; Dieter Steinhilber; Bengt Samuelsson; Olof Rådmark

Biochem J (2010) 425 (1): 265–274.

Abstract

View Articletitled, Coactosin-like protein functions as a stabilizing chaperone for 5-lipoxygenase: role of tryptophan 102

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Wild-type and missense mutants of retinoschisin co-assemble resulting in either intracellular retention or incorrect assembly of the functionally active octamer

Lindsay J. Gleghorn; Dorothy Trump; Neil J. Bulleid

Biochem J (2010) 425 (1): 275–284.

Abstract

View Articletitled, Wild-type and missense mutants of retinoschisin co-assemble resulting in either intracellular retention or incorrect assembly of the functionally active octamer

Supplementary data

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Serotonin as a physiological substrate for myeloperoxidase and its superoxide-dependent oxidation to cytotoxic tryptamine-4,5-dione

Valdecir F. Ximenes; Ghassan J. Maghzal; Rufus Turner; Yoji Kato; Christine C. Winterbourn; Anthony J. Kettle

Biochem J (2010) 425 (1): 285–293.

Abstract

View Articletitled, Serotonin as a physiological substrate for myeloperoxidase and its superoxide-dependent oxidation to cytotoxic tryptamine-4,5-dione

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Commentaries

Caught in the middle: the role of Bag3 in disease

Andrea K. McCollum; Giovanna Casagrande; Elise C. Kohn

Biochem J (2010) 425 (1): e1–e3.

Abstract

View Articletitled, Caught in the middle: the role of Bag3 in disease

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Structural commonalities determined by physicochemical principles in the complex polymorphism of the amyloid state of proteins

Structure, kinetics, and mechanism of Pseudomonas putida sulfoquinovose dehydrogenase, the first enzyme in the sulfoglycolytic Entner-Doudoroff pathway

Inhibition of RIPK1 or RIPK3 kinase activity post ischemia-reperfusion reduces the development of chronic kidney injury

Nucleic acid joining enzymes: biological functions and synthetic applications beyond DNA

In silico, in vitro and in vivo characterisation of thiamin binding proteins from plant seeds

Review articles

‘Unknown’ proteins and ‘orphan’ enzymes: the missing half of the engineering parts list – and how to find it

Molecular mechanisms of metabolic regulation by insulin in Drosophila

Breaking the code: Ca²⁺ sensors in plant signalling

Transcriptional and post-translational regulation of adiponectin

Guidelines for the effective use of chemical inhibitors of protein function to understand their roles in cell regulation

Research articles

An allosteric transition trapped in an intermediate state of a new kinesin–inhibitor complex

Targeting of inositol 1,4,5-trisphosphate receptor to the endoplasmic reticulum by its first transmembrane domain

Brd2 disruption in mice causes severe obesity without Type 2 diabetes

Structural and functional analysis of the intrinsic inhibitor subunit ϵ of F₁-ATPase from photosynthetic organisms

SCG10-like protein (SCLIP) is a STAT3-interacting protein involved in maintaining epithelial morphology in MCF-7 breast cancer cells

PBX1 and MEIS1 up-regulate SOX3 gene expression by direct interaction with a consensus binding site within the basal promoter region

Positive contribution of ERdj5/JPDI to endoplasmic reticulum protein quality control in the salivary gland

Molecular identification of aspartate N-acetyltransferase and its mutation in hypoacetylaspartia

Mitochondrial targeting of cyclosporin A enables selective inhibition of cyclophilin-D and enhanced cytoprotection after glucose and oxygen deprivation

Comparison of the cellular and biochemical properties of Plasmodium falciparum choline and ethanolamine kinases

Role of phosphoinositides in STIM1 dynamics and store-operated calcium entry

G-protein-coupled-receptor kinases mediate TNFα-induced NF-κB signalling via direct interaction with and phosphorylation of IκBα

Reversible bleb formation in mast cells stimulated with antigen is Ca²⁺/calmodulin-dependent and bleb size is regulated by ARF6

A di-arginine motif contributes to the ER localization of the type I transmembrane ER oxidoreductase TMX4

Chloroplast HCF101 is a scaffold protein for [4Fe-4S] cluster assembly

C/EBP transcription factors regulate SREBP1c gene expression during adipogenesis

Fas/CD95 down-regulation in lymphoma cells through acquired alkyllysophospholipid resistance: partial role of associated sphingomyelin deficiency

Regulatory factors controlling transcription of Saccharomyces cerevisiae IXR1 by oxygen levels: a model of transcriptional adaptation from aerobiosis to hypoxia implicating ROX1 and IXR1 cross-regulation

Identification of the key structural motifs involved in HspB8/HspB6–Bag3 interaction

Role of the cysteine protease interpain A of Prevotella intermedia in breakdown and release of haem from haemoglobin

Coactosin-like protein functions as a stabilizing chaperone for 5-lipoxygenase: role of tryptophan 102

Wild-type and missense mutants of retinoschisin co-assemble resulting in either intracellular retention or incorrect assembly of the functionally active octamer

Serotonin as a physiological substrate for myeloperoxidase and its superoxide-dependent oxidation to cytotoxic tryptamine-4,5-dione

Commentaries

Caught in the middle: the role of Bag3 in disease

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