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Volume 436, Issue 2

June 2011

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Cover Image

Cover Image
Front Matter
Table of Contents
Editorial Board

ISSN 0264-6021

EISSN 1470-8728

In this Issue

Review articles
Accelerated Publications
Research articles
Commentaries

Review articles

The role of amino acid transporters in inherited and acquired diseases

Stefan Bröer; Manuel Palacín

Biochem J (2011) 436 (2): 193–211.

Abstract

View Articletitled, The role of amino acid transporters in inherited and acquired diseases

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The Hippo pathway and apico–basal cell polarity

Alice Genevet; Nicolas Tapon

Biochem J (2011) 436 (2): 213–224.

Abstract

View Articletitled, The Hippo pathway and apico–basal cell polarity

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Accelerated Publications

Reversible membrane reorganizations during photosynthesis in vivo: revealed by small-angle neutron scattering

Gergely Nagy; Dorthe Posselt; László Kovács; Jens K. Holm; Milán Szabó; Bettina Ughy; László Rosta; Judith Peters; Peter Timmins; Győző Garab

Biochem J (2011) 436 (2): 225–230.

Abstract

View Articletitled, Reversible membrane reorganizations during photosynthesis in vivo: revealed by small-angle neutron scattering

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Research articles

InsP₃ receptors and Orai channels in pancreatic acinar cells: co-localization and its consequences

Gyorgy Lur; Mark W. Sherwood; Etsuko Ebisui; Lee Haynes; Stefan Feske; Robert Sutton; Robert D. Burgoyne; Katsuhiko Mikoshiba; Ole H. Petersen; Alexei V. Tepikin

Biochem J (2011) 436 (2): 231–239.

Abstract

View Articletitled, InsP3 receptors and Orai channels in pancreatic acinar cells: co-localization and its consequences

Supplementary data

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Molecular dynamics analysis of conserved hydrophobic and hydrophilic bond-interaction networks in ErbB family kinases

Andrew J. Shih; Shannon E. Telesco; Sung-Hee Choi; Mark A. Lemmon; Ravi Radhakrishnan

Biochem J (2011) 436 (2): 241–251.

Abstract

View Articletitled, Molecular dynamics analysis of conserved hydrophobic and hydrophilic bond-interaction networks in ErbB family kinases

Supplementary data

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RANKL induces NFATc1 acetylation and stability via histone acetyltransferases during osteoclast differentiation

Jung Ha Kim; Kabsun Kim; Bang Ung Youn; Hye Mi Jin; Ji-Young Kim; Jang Bae Moon; Aeran Ko; Sang-Beom Seo; Kwang-Youl Lee; Nacksung Kim

Biochem J (2011) 436 (2): 253–262.

Abstract

View Articletitled, RANKL induces NFATc1 acetylation and stability via histone acetyltransferases during osteoclast differentiation

Supplementary data

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Mest/Peg1 inhibits Wnt signalling through regulation of LRP6 glycosylation

Hwajin Jung; Suk Kyung Lee; Eek-hoon Jho

Biochem J (2011) 436 (2): 263–269.

Abstract

View Articletitled, Mest/Peg1 inhibits Wnt signalling through regulation of LRP6 glycosylation

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Silencing of hHS6ST2 inhibits progression of pancreatic cancer through inhibition of Notch signalling

Kai Song; Qin Li; Yong-Bo Peng; Jie Li; Kan Ding; Li-Juan Chen; Cheng-Hao Shao; Li-Jun Zhang; Ping Li

Biochem J (2011) 436 (2): 271–282.

Abstract

View Articletitled, Silencing of hHS6ST2 inhibits progression of pancreatic cancer through inhibition of Notch signalling

Supplementary data

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Structures of the substrate-binding protein provide insights into the multiple compatible solute binding specificities of the Bacillus subtilis ABC transporter OpuC

Yang Du; Wei-Wei Shi; Yong-Xing He; Yi-Hu Yang; Cong-Zhao Zhou; Yuxing Chen

Biochem J (2011) 436 (2): 283–289.

Abstract

View Articletitled, Structures of the substrate-binding protein provide insights into the multiple compatible solute binding specificities of the Bacillus subtilis ABC transporter OpuC

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Stability and function of the Sec61 translocation complex depends on the Sss1p tail-anchor sequence

Domina Falcone; Matthew P. Henderson; Hendrik Nieuwland; Christine M. Coughlan; Jeffrey L. Brodsky; David W. Andrews

Biochem J (2011) 436 (2): 291–303.

Abstract

View Articletitled, Stability and function of the Sec61 translocation complex depends on the Sss1p tail-anchor sequence

Supplementary data

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OAT2 catalyses efflux of glutamate and uptake of orotic acid

Christian Fork; Tim Bauer; Stefan Golz; Andreas Geerts; Jessica Weiland; Domenico Del Turco; Edgar Schömig; Dirk Gründemann

Biochem J (2011) 436 (2): 305–312.

Abstract

View Articletitled, OAT2 catalyses efflux of glutamate and uptake of orotic acid

Supplementary data

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Substrate binding disrupts dimerization and induces nucleotide exchange of the chloroplast GTPase Toc33

Mislav Oreb; Anja Höfle; Patrick Koenig; Maik S. Sommer; Irmgard Sinning; Fei Wang; Ivo Tews; Danny J. Schnell; Enrico Schleiff

Biochem J (2011) 436 (2): 313–319.

Abstract

View Articletitled, Substrate binding disrupts dimerization and induces nucleotide exchange of the chloroplast GTPase Toc33

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The crystal structure of the cephalosporin deacetylating enzyme acetyl xylan esterase bound to paraoxon explains the low sensitivity of this serine hydrolase to organophosphate inactivation

Silvia Montoro-García; Fernando Gil-Ortiz; Francisco García-Carmona; Luis Mariano Polo; Vicente Rubio; Álvaro Sánchez-Ferrer

Biochem J (2011) 436 (2): 321–330.

Abstract

View Articletitled, The crystal structure of the cephalosporin deacetylating enzyme acetyl xylan esterase bound to paraoxon explains the low sensitivity of this serine hydrolase to organophosphate inactivation

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Structural basis for CARM1 inhibition by indole and pyrazole inhibitors

John S. Sack; Sandrine Thieffine; Tiziano Bandiera; Marina Fasolini; Gerald J. Duke; Lata Jayaraman; Kevin F. Kish; Herbert E. Klei; Ashok V. Purandare; Pamela Rosettani; Sonia Troiani; Dianlin Xie; Jay A. Bertrand

Biochem J (2011) 436 (2): 331–339.

Abstract

View Articletitled, Structural basis for CARM1 inhibition by indole and pyrazole inhibitors

Supplementary data

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Substrate diffusion and oxidation in GMC oxidoreductases: an experimental and computational study on fungal aryl-alcohol oxidase

Aitor Hernández-Ortega; Kenneth Borrelli; Patricia Ferreira; Milagros Medina; Angel T. Martínez; Victor Guallar

Biochem J (2011) 436 (2): 341–350.

Abstract

View Articletitled, Substrate diffusion and oxidation in GMC oxidoreductases: an experimental and computational study on fungal aryl-alcohol oxidase

Supplementary data

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Glucan particles for selective delivery of siRNA to phagocytic cells in mice

Gregory J. Tesz; Myriam Aouadi; Matthieu Prot; Sarah M. Nicoloro; Emilie Boutet; Shinya U. Amano; Anca Goller; Mengxi Wang; Chang-An Guo; William E. Salomon; Joseph V. Virbasius; Rebecca A. Baum; Mark J. O'Connor, Jr; Ernesto Soto; Gary R. Ostroff; Michael P. Czech

Biochem J (2011) 436 (2): 351–362.

Abstract

View Articletitled, Glucan particles for selective delivery of siRNA to phagocytic cells in mice

Supplementary data

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Biochemical characterization of human HIF hydroxylases using HIF protein substrates that contain all three hydroxylation sites

Melissa B. Pappalardi; Dean E. McNulty; John D. Martin; Kelly E. Fisher; Yong Jiang; Matthew C. Burns; Huizhen Zhao; Thau Ho; Sharon Sweitzer; Benjamin Schwartz; Roland S. Annan; Robert A. Copeland; Peter J. Tummino; Lusong Luo

Biochem J (2011) 436 (2): 363–369.

Abstract

View Articletitled, Biochemical characterization of human HIF hydroxylases using HIF protein substrates that contain all three hydroxylation sites

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A single point mutation in ricin A-chain increases toxin degradation and inhibits EDEM1-dependent ER retrotranslocation

Iwona Sokołowska; Sébastien Wälchli; Grzegorz Węgrzyn; Kirsten Sandvig; Monika Słomińska-Wojewódzka

Biochem J (2011) 436 (2): 371–385.

Abstract

View Articletitled, A single point mutation in ricin A-chain increases toxin degradation and inhibits EDEM1-dependent ER retrotranslocation

Supplementary data

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The novel Nrf2-interacting factor KAP1 regulates susceptibility to oxidative stress by promoting the Nrf2-mediated cytoprotective response

Atsushi Maruyama; Keizo Nishikawa; Yukie Kawatani; Junsei Mimura; Tomonori Hosoya; Nobuhiko Harada; Masayuki Yamamato; Ken Itoh

Biochem J (2011) 436 (2): 387–397.

Abstract

View Articletitled, The novel Nrf2-interacting factor KAP1 regulates susceptibility to oxidative stress by promoting the Nrf2-mediated cytoprotective response

Supplementary data

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Hypoxia down-regulates sFlt-1 (sVEGFR-1) expression in human microvascular endothelial cells by a mechanism involving mRNA alternative processing

Takayuki Ikeda; Li Sun; Naoki Tsuruoka; Yasuhito Ishigaki; Yasuo Yoshitomi; Yoshino Yoshitake; Hideto Yonekura

Biochem J (2011) 436 (2): 399–407.

Abstract

View Articletitled, Hypoxia down-regulates sFlt-1 (sVEGFR-1) expression in human microvascular endothelial cells by a mechanism involving mRNA alternative processing

Supplementary data

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The interplay of DNA binding, ATP hydrolysis and helicase activities of the archaeal MCM helicase

Li Phing Liew; Stephen D. Bell

Biochem J (2011) 436 (2): 409–414.

Abstract

View Articletitled, The interplay of DNA binding, ATP hydrolysis and helicase activities of the archaeal MCM helicase

Supplementary data

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Movement of hClC-1 C-termini during common gating and limits on their cytoplasmic location

Linlin Ma; Grigori Y. Rychkov; Ekaterina A. Bykova; Jie Zheng; Allan H. Bretag

Biochem J (2011) 436 (2): 415–428.

Abstract

View Articletitled, Movement of hClC-1 C-termini during common gating and limits on their cytoplasmic location

Supplementary data

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The phytotoxin fusicoccin promotes platelet aggregation via 14-3-3–glycoprotein Ib-IX-V interaction

Lorenzo Camoni; Cristina Di Lucente; Sabina Visconti; Patrizia Aducci

Biochem J (2011) 436 (2): 429–436.

Abstract

View Articletitled, The phytotoxin fusicoccin promotes platelet aggregation via 14-3-3–glycoprotein Ib-IX-V interaction

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Slow skeletal muscle myosin-binding protein-C (MyBPC1) mediates recruitment of muscle-type creatine kinase (CK) to myosin

Zhe Chen; Tong-Jin Zhao; Jie Li; Yan-Song Gao; Fan-Guo Meng; Yong-Bin Yan; Hai-Meng Zhou

Biochem J (2011) 436 (2): 437–445.

Abstract

View Articletitled, Slow skeletal muscle myosin-binding protein-C (MyBPC1) mediates recruitment of muscle-type creatine kinase (CK) to myosin

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Biochemical correlation of activity of the α-dystroglycan-modifying glycosyltransferase POMGnT1 with mutations in muscle-eye-brain disease

Josef Voglmeir; Sara Kaloo; Nicolas Laurent; Marco M. Meloni; Lisa Bohlmann; Iain B. H. Wilson; Sabine L. Flitsch

Biochem J (2011) 436 (2): 447–455.

Abstract

View Articletitled, Biochemical correlation of activity of the α-dystroglycan-modifying glycosyltransferase POMGnT1 with mutations in muscle-eye-brain disease

Supplementary data

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Testes-specific protease 50 (TSP50) promotes cell proliferation through the activation of the nuclear factor κB (NF-κB) signalling pathway

Zhen-Bo Song; Yong-Li Bao; Yu Zhang; Xu-Guang Mi; Ping Wu; Yin Wu; Chun-Lei Yu; Ying Sun; Li-Hua Zheng; Yan-Xin Huang; Biao Liu; Yu-Xin Li

Biochem J (2011) 436 (2): 457–467.

Abstract

View Articletitled, Testes-specific protease 50 (TSP50) promotes cell proliferation through the activation of the nuclear factor κB (NF-κB) signalling pathway

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Protease-activated receptor 1 (PAR1) signalling desensitization is counteracted via PAR4 signalling in human platelets

Knut Fälker; Linda Haglund; Peter Gunnarsson; Martina Nylander; Tomas L. Lindahl; Magnus Grenegård

Biochem J (2011) 436 (2): 469–480.

Abstract

View Articletitled, Protease-activated receptor 1 (PAR1) signalling desensitization is counteracted via PAR4 signalling in human platelets

Supplementary data

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Clioquinol induces cytoplasmic clearance of the X-linked inhibitor of apoptosis protein (XIAP): therapeutic indication for prostate cancer

Michael A. Cater; Ygal Haupt

Biochem J (2011) 436 (2): 481–491.

Abstract

View Articletitled, Clioquinol induces cytoplasmic clearance of the X-linked inhibitor of apoptosis protein (XIAP): therapeutic indication for prostate cancer

Supplementary data

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The role of oxidized cytochrome c in regulating mitochondrial reactive oxygen species production and its perturbation in ischaemia

Philippe Pasdois; Joanne E. Parker; Elinor J. Griffiths; Andrew P. Halestrap

Biochem J (2011) 436 (2): 493–505.

Abstract

View Articletitled, The role of oxidized cytochrome c in regulating mitochondrial reactive oxygen species production and its perturbation in ischaemia

Supplementary data

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Insulin-like growth factor 1 activates methionine adenosyltransferase 2A transcription by multiple pathways in human colon cancer cells

Heping Yang; Tony W. H. Li; Jian Peng; José M. Mato; Shelly C. Lu

Biochem J (2011) 436 (2): 507–516.

Abstract

View Articletitled, Insulin-like growth factor 1 activates methionine adenosyltransferase 2A transcription by multiple pathways in human colon cancer cells

Supplementary data

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Commentaries

Dimerization of TOC receptor GTPases and its implementation for the control of protein import into chloroplasts

Henrik Aronsson; Paul Jarvis

Biochem J (2011) 436 (2): e1–e2.

Abstract

View Articletitled, Dimerization of TOC receptor GTPases and its implementation for the control of protein import into chloroplasts

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The continued evolution of the L2 cephalosporinase in Stenotrophomonas maltophilia: A key driver of beta-lactam resistance

Noncanonical RGS14 structural determinants control hormone-sensitive NPT2A-mediated phosphate transport

The MYO1B and MYO5B motor proteins and the sorting nexin SNX27 regulate apical targeting of membrane mucin MUC17 in enterocytes

Specialized killing across the domains of life by the type VI secretion systems of Pseudomonas aeruginosa

DNA binding of an RNA helicase bacterial transcription terminator

Review articles

The role of amino acid transporters in inherited and acquired diseases

The Hippo pathway and apico–basal cell polarity

Accelerated Publications

Reversible membrane reorganizations during photosynthesis in vivo: revealed by small-angle neutron scattering

Research articles

InsP₃ receptors and Orai channels in pancreatic acinar cells: co-localization and its consequences

Molecular dynamics analysis of conserved hydrophobic and hydrophilic bond-interaction networks in ErbB family kinases

RANKL induces NFATc1 acetylation and stability via histone acetyltransferases during osteoclast differentiation

Mest/Peg1 inhibits Wnt signalling through regulation of LRP6 glycosylation

Silencing of hHS6ST2 inhibits progression of pancreatic cancer through inhibition of Notch signalling

Structures of the substrate-binding protein provide insights into the multiple compatible solute binding specificities of the Bacillus subtilis ABC transporter OpuC

Stability and function of the Sec61 translocation complex depends on the Sss1p tail-anchor sequence

OAT2 catalyses efflux of glutamate and uptake of orotic acid

Substrate binding disrupts dimerization and induces nucleotide exchange of the chloroplast GTPase Toc33

The crystal structure of the cephalosporin deacetylating enzyme acetyl xylan esterase bound to paraoxon explains the low sensitivity of this serine hydrolase to organophosphate inactivation

Structural basis for CARM1 inhibition by indole and pyrazole inhibitors

Substrate diffusion and oxidation in GMC oxidoreductases: an experimental and computational study on fungal aryl-alcohol oxidase

Glucan particles for selective delivery of siRNA to phagocytic cells in mice

Biochemical characterization of human HIF hydroxylases using HIF protein substrates that contain all three hydroxylation sites

A single point mutation in ricin A-chain increases toxin degradation and inhibits EDEM1-dependent ER retrotranslocation

The novel Nrf2-interacting factor KAP1 regulates susceptibility to oxidative stress by promoting the Nrf2-mediated cytoprotective response

Hypoxia down-regulates sFlt-1 (sVEGFR-1) expression in human microvascular endothelial cells by a mechanism involving mRNA alternative processing

The interplay of DNA binding, ATP hydrolysis and helicase activities of the archaeal MCM helicase

Movement of hClC-1 C-termini during common gating and limits on their cytoplasmic location

The phytotoxin fusicoccin promotes platelet aggregation via 14-3-3–glycoprotein Ib-IX-V interaction

Slow skeletal muscle myosin-binding protein-C (MyBPC1) mediates recruitment of muscle-type creatine kinase (CK) to myosin

Biochemical correlation of activity of the α-dystroglycan-modifying glycosyltransferase POMGnT1 with mutations in muscle-eye-brain disease

Testes-specific protease 50 (TSP50) promotes cell proliferation through the activation of the nuclear factor κB (NF-κB) signalling pathway

Protease-activated receptor 1 (PAR1) signalling desensitization is counteracted via PAR4 signalling in human platelets

Clioquinol induces cytoplasmic clearance of the X-linked inhibitor of apoptosis protein (XIAP): therapeutic indication for prostate cancer

The role of oxidized cytochrome c in regulating mitochondrial reactive oxygen species production and its perturbation in ischaemia

Insulin-like growth factor 1 activates methionine adenosyltransferase 2A transcription by multiple pathways in human colon cancer cells

Commentaries

Dimerization of TOC receptor GTPases and its implementation for the control of protein import into chloroplasts

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