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January 2012
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ISSN 0264-6021
EISSN 1470-8728
In this Issue
Review articles
Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks
Biochem J (2012) 441 (1): 1–21.
Multiple roles for the p85α isoform in the regulation and function of PI3K signalling and receptor trafficking
Biochem J (2012) 441 (1): 23–37.
Insights into the PX (phox-homology) domain and SNX (sorting nexin) protein families: structures, functions and roles in disease
Biochem J (2012) 441 (1): 39–59.
Research articles
Dissecting structure–function–stability relationships of a thermostable GH5-CBM3 cellulase from Bacillus subtilis 168
Camila R. Santos; Joice H. Paiva; Maurício L. Sforça; Jorge L. Neves; Rodrigo Z. Navarro; Júnio Cota; Patrícia K. Akao; Zaira B. Hoffmam; Andréia N. Meza; Juliana H. Smetana; Maria L. Nogueira; Igor Polikarpov; José Xavier-Neto; Fábio M. Squina; Richard J. Ward; Roberto Ruller; Ana C. Zeri; Mário T. Murakami
Biochem J (2012) 441 (1): 95–104.
Determinants of the enzymatic activity and the subcellular localization of aspartate N-acetyltransferase
Biochem J (2012) 441 (1): 105–112.
Structural insights into the peroxidase activity and inactivation of human peroxiredoxin 4
Biochem J (2012) 441 (1): 113–118.
Critical roles of RNA helicase DDX3 and its interactions with eIF4E/PABP1 in stress granule assembly and stress response
Biochem J (2012) 441 (1): 119–129.
The high-resolution crystal structure of periplasmic Haemophilus influenzae NAD nucleotidase reveals a novel enzymatic function of human CD73 related to NAD metabolism
Silvia Garavaglia; Santina Bruzzone; Camilla Cassani; Laura Canella; Gianna Allegrone; Laura Sturla; Elena Mannino; Enrico Millo; Antonio De Flora; Menico Rizzi
Biochem J (2012) 441 (1): 131–141.
Length of the active-site crossover loop defines the substrate specificity of ubiquitin C-terminal hydrolases for ubiquitin chains
Biochem J (2012) 441 (1): 143–149.
Insights into subtle conformational differences in the substrate-binding loop of fungal 17β-hydroxysteroid dehydrogenase: a combined structural and kinetic approach
Alberto Cassetta; Ivet Krastanova; Katja Kristan; Mojca Brunskole Švegelj; Doriano Lamba; Tea Lanišnik Rižner; Jure Stojan
Biochem J (2012) 441 (1): 151–160.
A novel class of PTEN protein in Arabidopsis displays unusual phosphoinositide phosphatase activity and efficiently binds phosphatidic acid
Anne Pribat; Rodnay Sormani; Mathieu Rousseau-Gueutin; Magdalena M. Julkowska; Christa Testerink; Jerôme Joubès; Michel Castroviejo; Michel Laguerre; Christian Meyer; Véronique Germain; Christophe Rothan
Biochem J (2012) 441 (1): 161–171.
Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2
Christian Krintel; Karla Frydenvang; Lars Olsen; Maria T. Kristensen; Oriol de Barrios; Peter Naur; Pierre Francotte; Bernard Pirotte; Michael Gajhede; Jette S. Kastrup
Biochem J (2012) 441 (1): 173–178.
Vitamin E isoforms directly bind PKCα and differentially regulate activation of PKCα
Christine A. McCary; Youngdae Yoon; Candace Panagabko; Wonhwa Cho; Jeffrey Atkinson; Joan M. Cook-Mills
Biochem J (2012) 441 (1): 189–198.
A global survey of CRM1-dependent nuclear export sequences in the human deubiquitinase family
Biochem J (2012) 441 (1): 209–217.
Adaptive evolution of drug targets in producer and non-producer organisms
Bjarne G. Hansen; Xin E. Sun; Hans J. Genee; Christian S. Kaas; Jakob B. Nielsen; Uffe H. Mortensen; Jens C. Frisvad; Lizbeth Hedstrom
Biochem J (2012) 441 (1): 219–226.
Targeted polyubiquitylation of RASSF1C by the Mule and SCFβ-TrCP ligases in response to DNA damage
Biochem J (2012) 441 (1): 227–236.
A novel role for protein kinase Gcn2 in yeast tolerance to intracellular acid stress
Guillem Hueso; Rafael Aparicio-Sanchis; Consuelo Montesinos; Silvia Lorenz; José R. Murguía; Ramón Serrano
Biochem J (2012) 441 (1): 255–264.
Relaxin-like factor (RLF)/insulin-like peptide 3 (INSL3) is secreted from testicular Leydig cells as a monomeric protein comprising three domains B–C–A with full biological activity in boars
Itaru Minagawa; Masafumi Fukuda; Hisako Ishige; Hiroshi Kohriki; Masatoshi Shibata; Enoch Y. Park; Tatsuo Kawarasaki; Tetsuya Kohsaka
Biochem J (2012) 441 (1): 265–273.
LRPPRC mutation suppresses cytochrome oxidase activity by altering mitochondrial RNA transcript stability in a mouse model
Biochem J (2012) 441 (1): 275–283.
Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice
Paul J. Meakin; Alex J. Harper; D. Lee Hamilton; Jennifer Gallagher; Alison D. McNeilly; Laura A. Burgess; Lobke M. Vaanholt; Kirsten A. Bannon; Judy Latcham; Ishrut Hussain; John R. Speakman; David R. Howlett; Michael L.J. Ashford
Biochem J (2012) 441 (1): 285–296.
Selenium-containing amino acids are targets for myeloperoxidase-derived hypothiocyanous acid: determination of absolute rate constants and implications for biological damage
Ojia Skaff; David I. Pattison; Philip E. Morgan; Rushad Bachana; Vimal K. Jain; K. Indira Priyadarsini; Michael J. Davies
Biochem J (2012) 441 (1): 305–316.
Identification of the protein kinases that activate the E3 ubiquitin ligase Pellino 1 in the innate immune system
Biochem J (2012) 441 (1): 339–346.
Characterization of the cellular action of the MSK inhibitor SB-747651A
Shaista Naqvi; Andrew Macdonald; Claire E. McCoy; Joanne Darragh; Alastair D. Reith; J. Simon C. Arthur
Biochem J (2012) 441 (1): 347–357.
PTEN interacts with metal-responsive transcription factor 1 and stimulates its transcriptional activity
Biochem J (2012) 441 (1): 367–377.
A common single nucleotide polymorphism A118G of the μ opioid receptor alters its N-glycosylation and protein stability
Biochem J (2012) 441 (1): 379–386.
Thr90 phosphorylation of Hsp90α by protein kinase A regulates its chaperone machinery
Biochem J (2012) 441 (1): 387–397.
Nedd4-dependent lysine-11-linked polyubiquitination of the tumour suppressor Beclin 1
Biochem J (2012) 441 (1): 399–406.
Phospholipase D1 mediates bFGF-induced Bcl-2 expression leading to neurite outgrowth in H19-7 cells
Biochem J (2012) 441 (1): 407–416.
Inhibition of polyglutamine-mediated proteotoxicity by Astragalus membranaceus polysaccharide through the DAF-16/FOXO transcription factor in Caenorhabditis elegans
Hanrui Zhang; Ni Pan; Siqin Xiong; Shenglong Zou; Haifeng Li; Lingyun Xiao; Zhijian Cao; Alan Tunnacliffe; Zebo Huang
Biochem J (2012) 441 (1): 417–424.
Selection of non-competitive leptin antagonists using a random nanobody-based approach
Lennart Zabeau; Annick Verhee; Dominiek Catteeuw; Liesbeth Faes; Sylvie Seeuws; Tine Decruy; Dirk Elewaut; Frank Peelman; Jan Tavernier
Biochem J (2012) 441 (1): 425–434.
NAADP regulates human platelet function
Carmen H. Coxon; Alexander M. Lewis; Amanda J. Sadler; Sridhar R. Vasudevan; Andrew Thomas; Kirsten A. Dundas; Lewis Taylor; R. Duncan Campbell; Jonathan M. Gibbins; Grant C. Churchill; Katherine L. Tucker
Biochem J (2012) 441 (1): 435–442.
Extravesicular intraneuronal migration of internalized botulinum neurotoxins without detectable inhibition of distal neurotransmission
Biochem J (2012) 441 (1): 443–452.
Neurotrophin-4 modulates the mechanotransducer Cav3.2 T-type calcium current in mice down-hair neurons
Biochem J (2012) 441 (1): 463–471.
Mutation in the Fe–S scaffold protein Isu bypasses frataxin deletion
Heeyong Yoon; Ramesh Golla; Emmanuel Lesuisse; Jayashree Pain; Jason E. Donald; Elise R. Lyver; Debkumar Pain; Andrew Dancis
Biochem J (2012) 441 (1): 473–480.
Location and dynamics of an active promoter in Escherichia coli K-12
Biochem J (2012) 441 (1): 481–485.
Directed evolution of a temperature-, peroxide- and alkaline pH-tolerant versatile peroxidase
Biochem J (2012) 441 (1): 487–498.
Characterization of a novel peripheral pro-lipolytic mechanism in mice: role of VGF-derived peptide TLQP-21
Roberta Possenti; Giampiero Muccioli; Pamela Petrocchi; Cheryl Cero; Aderville Cabassi; Lucy Vulchanova; Maureen S. Riedl; Monia Manieri; Andrea Frontini; Antonio Giordano; Saverio Cinti; Paolo Govoni; Gallia Graiani; Federico Quaini; Corrado Ghè; Elena Bresciani; Ilaria Bulgarelli; Antonio Torsello; Vittorio Locatelli; Valentina Sanghez; Bjarne D. Larsen; Jorgen S. Petersen; Paola Palanza; Stefano Parmigiani; Anna Moles; Andrea Levi; Alessandro Bartolomucci
Biochem J (2012) 441 (1): 511–522.
