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Volume 443, Issue 3

May 2012

All Issues

Cover Image

Cover Image
Front Matter
Table of Contents
Editorial Board

ISSN 0264-6021

EISSN 1470-8728

In this Issue

Review articles
Accelerated Publications
Research articles
Accelerated Publications
Research articles
Commentaries

Review articles

Regulation and cellular functions of class II phosphoinositide 3-kinases

Marco Falasca; Tania Maffucci

Biochem J (2012) 443 (3): 587–601.

Abstract

View Articletitled, Regulation and cellular functions of class II phosphoinositide 3-kinases

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Lentiviral vectors: basic to translational

Toshie Sakuma; Michael A. Barry; Yasuhiro Ikeda

Biochem J (2012) 443 (3): 603–618.

Abstract

View Articletitled, Lentiviral vectors: basic to translational

Supplementary data

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Accelerated Publications

Mutual co-regulation between GPI-N-acetylglucosaminyltransferase and ergosterol biosynthesis in Candida albicans

Guiliana Soraya Victoria; Bhawna Yadav; Lalremruata Hauhnar; Priyanka Jain; Shilpi Bhatnagar; Sneha Sudha Komath

Biochem J (2012) 443 (3): 619–625.

Abstract

View Articletitled, Mutual co-regulation between GPI-N-acetylglucosaminyltransferase and ergosterol biosynthesis in Candida albicans

Supplementary data

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An activity-based probe reveals dynamic protein–protein interactions mediating IGF-1R transactivation by the GABA_B receptor

Xin Lin; Xin Li; Ming Jiang; Linhai Chen; Chanjuan Xu; Wenhua Zhang; Han Zhao; Bing Sun; Xiaoli Xu; Fajun Nan; Jianfeng Liu

Biochem J (2012) 443 (3): 627–634.

Abstract

View Articletitled, An activity-based probe reveals dynamic protein–protein interactions mediating IGF-1R transactivation by the GABAB receptor

Supplementary data

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Research articles

Readthrough of long-QT syndrome type 1 nonsense mutations rescues function but alters the biophysical properties of the channel

Stephen C. Harmer; Jagdeep S. Mohal; Duncan Kemp; Andrew Tinker

Biochem J (2012) 443 (3): 635–642.

Abstract

View Articletitled, Readthrough of long-QT syndrome type 1 nonsense mutations rescues function but alters the biophysical properties of the channel

Supplementary data

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Identification of the topology and functional domains of PAQR10

Ting Jin; Daqian Xu; Qiurong Ding; Yixuan Zhang; Chenqian Mao; Yi Pan; Zhenzhen Wang; Yan Chen

Biochem J (2012) 443 (3): 643–653.

Abstract

View Articletitled, Identification of the topology and functional domains of PAQR10

Supplementary data

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Identification of a molecular component of the mitochondrial acetyltransferase programme: a novel role for GCN5L1

Iain Scott; Bradley R. Webster; Jian H. Li; Michael N. Sack

Biochem J (2012) 443 (3): 655–661.

Abstract

View Articletitled, Identification of a molecular component of the mitochondrial acetyltransferase programme: a novel role for GCN5L1

Supplementary data

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Role of individual phosphorylation sites for the 14-3-3-protein-dependent activation of yeast neutral trehalase Nth1

Dana Veisova; Eva Macakova; Lenka Rezabkova; Miroslav Sulc; Petr Vacha; Hana Sychrova; Tomas Obsil; Veronika Obsilova

Biochem J (2012) 443 (3): 663–670.

Abstract

View Articletitled, Role of individual phosphorylation sites for the 14-3-3-protein-dependent activation of yeast neutral trehalase Nth1

Supplementary data

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Crystal structure of the enzyme CapF of Staphylococcus aureus reveals a unique architecture composed of two functional domains

Takamitsu Miyafusa; Jose M. M. Caaveiro; Yoshikazu Tanaka; Kouhei Tsumoto

Biochem J (2012) 443 (3): 671–680.

Abstract

View Articletitled, Crystal structure of the enzyme CapF of Staphylococcus aureus reveals a unique architecture composed of two functional domains

Supplementary data

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Degradation of mutant huntingtin via the ubiquitin/proteasome system is modulated by FE65

Wan Ning Vanessa Chow; Hon Wing Luk; Ho Yin Edwin Chan; Kwok-Fai Lau

Biochem J (2012) 443 (3): 681–689.

Abstract

View Articletitled, Degradation of mutant huntingtin via the ubiquitin/proteasome system is modulated by FE65

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Cross-talk between TGFβ1 and EGFR signalling pathways induces TM4SF5 expression and epithelial–mesenchymal transition

Minkyung Kang; Suyong Choi; Soo-Jin Jeong; Sin-Ae Lee; Tae Kyoung Kwak; Hyeonjung Kim; Oisun Jung; Mi-Sook Lee; Youra Ko; Jihye Ryu; Yoon-Ju Choi; Doyoung Jeong; Hyo Jeong Lee; Sang-Kyu Ye; Sung-Hoon Kim; Jung Weon Lee

Biochem J (2012) 443 (3): 691–700.

Abstract

View Articletitled, Cross-talk between TGFβ1 and EGFR signalling pathways induces TM4SF5 expression and epithelial–mesenchymal transition

Supplementary data

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Conformational transitions of proteins engaged in DNA double-strand break repair, analysed by tryptophan fluorescence emission and FRET

Katia Stankova; Katia Ivanova; Emil Mladenov; Bustanur Rosidi; Aparna Sharma; Rayna Boteva; George Iliakis

Biochem J (2012) 443 (3): 701–709.

Abstract

View Articletitled, Conformational transitions of proteins engaged in DNA double-strand break repair, analysed by tryptophan fluorescence emission and FRET

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Cadherin binding is not a limiting step for Bacillus thuringiensis subsp. israelensis Cry4Ba toxicity to Aedes aegypti larvae

Claudia Rodríguez-Almazán; Esmeralda Z. Reyes; Fernando Zúñiga-Navarrete; Carlos Muñoz-Garay; Isabel Gómez; Amy M. Evans; Supaporn Likitvivatanavong; Alejandra Bravo; Sarjeet S. Gill; Mario Soberón

Biochem J (2012) 443 (3): 711–717.

Abstract

View Articletitled, Cadherin binding is not a limiting step for Bacillus thuringiensis subsp. israelensis Cry4Ba toxicity to Aedes aegypti larvae

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Toxic prefibrillar α-synuclein amyloid oligomers adopt a distinctive antiparallel β-sheet structure

María Soledad Celej; Rabia Sarroukh; Erik Goormaghtigh; Gerardo D. Fidelio; Jean-Marie Ruysschaert; Vincent Raussens

Biochem J (2012) 443 (3): 719–726.

Abstract

View Articletitled, Toxic prefibrillar α-synuclein amyloid oligomers adopt a distinctive antiparallel β-sheet structure

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Characterization of and functional evidence for Ste27 of Streptomyces sp. 139 as a novel spermine/spermidine acetyltransferase

Yang Zhang; Jinming Zhou; Ming Chang; Liping Bai; Junjie Shan; Chen Yao; Rong Jiang; Lianhong Guo; Ren Zhang; Jiangbo Wu; Yuan Li

Biochem J (2012) 443 (3): 727–734.

Abstract

View Articletitled, Characterization of and functional evidence for Ste27 of Streptomyces sp. 139 as a novel spermine/spermidine acetyltransferase

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CS055 (Chidamide/HBI-8000), a novel histone deacetylase inhibitor, induces G₁ arrest, ROS-dependent apoptosis and differentiation in human leukaemia cells

Ke Gong; Jia Xie; Hong Yi; Wenhua Li

Biochem J (2012) 443 (3): 735–746.

Abstract

View Articletitled, CS055 (Chidamide/HBI-8000), a novel histone deacetylase inhibitor, induces G1 arrest, ROS-dependent apoptosis and differentiation in human leukaemia cells

Supplementary data

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Cytosolic Ca²⁺ regulates the energization of isolated brain mitochondria by formation of pyruvate through the malate–aspartate shuttle

Frank Norbert Gellerich; Zemfira Gizatullina; Sonata Trumbekaite; Bernard Korzeniewski; Timur Gaynutdinov; Enn Seppet; Stefan Vielhaber; Hans-Jochen Heinze; Frank Striggow

Biochem J (2012) 443 (3): 747–755.

Abstract

View Articletitled, Cytosolic Ca2+ regulates the energization of isolated brain mitochondria by formation of pyruvate through the malate–aspartate shuttle

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The novel function of HINFP as a co-activator in sterol-regulated transcription of PCSK9 in HepG2 cells

Hai Li; Jingwen Liu

Biochem J (2012) 443 (3): 757–768.

Abstract

View Articletitled, The novel function of HINFP as a co-activator in sterol-regulated transcription of PCSK9 in HepG2 cells

Supplementary data

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Transthyretin is a metallopeptidase with an inducible active site

Márcia A. Liz; Sérgio C. Leite; Luiz Juliano; Maria J. Saraiva; Ana M. Damas; Daniel Bur; Mónica M. Sousa

Biochem J (2012) 443 (3): 769–778.

Abstract

View Articletitled, Transthyretin is a metallopeptidase with an inducible active site

Supplementary data

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The mouse Mageb18 gene encodes a ubiquitously expressed type I MAGE protein and regulates cell proliferation and apoptosis in melanoma B16-F0 cells

Yuquan Lin; Ti Wen; Xianyi Meng; Zhenzhou Wu; Liqing Zhao; Puyue Wang; Zhangyong Hong; Zhinan Yin

Biochem J (2012) 443 (3): 779–788.

Abstract

View Articletitled, The mouse Mageb18 gene encodes a ubiquitously expressed type I MAGE protein and regulates cell proliferation and apoptosis in melanoma B16-F0 cells

Supplementary data

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Indian Hedgehog signalling triggers Nkx3.2 protein degradation during chondrocyte maturation

Seung-Won Choi; Da-Un Jeong; Jeong-Ah Kim; Boyoung Lee; Kyu Sang Joeng; Fanxin Long; Dae-Won Kim

Biochem J (2012) 443 (3): 789–798.

Abstract

View Articletitled, Indian Hedgehog signalling triggers Nkx3.2 protein degradation during chondrocyte maturation

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Pref-1 in brown adipose tissue: specific involvement in brown adipocyte differentiation and regulatory role of C/EBPδ

Jordi Armengol; Josep A. Villena; Elayne Hondares; María C. Carmona; Hei Sook Sul; Roser Iglesias; Marta Giralt; Francesc Villarroya

Biochem J (2012) 443 (3): 799–810.

Abstract

View Articletitled, Pref-1 in brown adipose tissue: specific involvement in brown adipocyte differentiation and regulatory role of C/EBPδ

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p53 Ser¹⁵ phosphorylation disrupts the p53–RPA70 complex and induces RPA70-mediated DNA repair in hypoxia

Esha Madan; Rajan Gogna; Uttam Pati

Biochem J (2012) 443 (3): 811–820.

Abstract

View Articletitled, p53 Ser15 phosphorylation disrupts the p53–RPA70 complex and induces RPA70-mediated DNA repair in hypoxia

Supplementary data

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Induction of NANOG expression by targeting promoter sequence with small activating RNA antagonizes retinoic acid-induced differentiation

Xiaoling Wang; Ji Wang; Vera Huang; Robert F. Place; Long-Cheng Li

Biochem J (2012) 443 (3): 821–828.

Abstract

View Articletitled, Induction of NANOG expression by targeting promoter sequence with small activating RNA antagonizes retinoic acid-induced differentiation

Supplementary data

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Fasting induces ketoacidosis and hypothermia in PDHK2/PDHK4-double-knockout mice

Nam Ho Jeoung; Yasmeen Rahimi; Pengfei Wu; W. N. Paul Lee; Robert A. Harris

Biochem J (2012) 443 (3): 829–839.

Abstract

View Articletitled, Fasting induces ketoacidosis and hypothermia in PDHK2/PDHK4-double-knockout mice

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The ligand specificity of the G-protein-coupled receptor GPR34

Lars Ritscher; Eva Engemaier; Claudia Stäubert; Ines Liebscher; Philipp Schmidt; Thomas Hermsdorf; Holger Römpler; Angela Schulz; Torsten Schöneberg

Biochem J (2012) 443 (3): 841–850.

Abstract

View Articletitled, The ligand specificity of the G-protein-coupled receptor GPR34

Supplementary data

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Accelerated Publications

Ivermectin is a specific inhibitor of importin α/β-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus

Kylie M. Wagstaff; Haran Sivakumaran; Steven M. Heaton; David Harrich; David A. Jans

Biochem J (2012) 443 (3): 851–856.

Abstract

View Articletitled, Ivermectin is a specific inhibitor of importin α/β-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus

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Research articles

Isoform-selective induction of human p110δ PI3K expression by TNFα: identification of a new and inducible PIK3CD promoter

Maria A. Whitehead; Michele Bombardieri; Costantino Pitzalis; Bart Vanhaesebroeck

Biochem J (2012) 443 (3): 857–867.

Abstract

View Articletitled, Isoform-selective induction of human p110δ PI3K expression by TNFα: identification of a new and inducible PIK3CD promoter

Supplementary data

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Commentaries

Pref-1 preferentially inhibits heat production in brown adipose tissue

Maryam Rakhshandehroo; Arjen Koppen; Eric Kalkhoven

Biochem J (2012) 443 (3): e3–e5.

Abstract

View Articletitled, Pref-1 preferentially inhibits heat production in brown adipose tissue

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Review articles

Regulation and cellular functions of class II phosphoinositide 3-kinases

Lentiviral vectors: basic to translational

Accelerated Publications

Mutual co-regulation between GPI-N-acetylglucosaminyltransferase and ergosterol biosynthesis in Candida albicans

An activity-based probe reveals dynamic protein–protein interactions mediating IGF-1R transactivation by the GABA_B receptor

Research articles

Readthrough of long-QT syndrome type 1 nonsense mutations rescues function but alters the biophysical properties of the channel

Identification of the topology and functional domains of PAQR10

Identification of a molecular component of the mitochondrial acetyltransferase programme: a novel role for GCN5L1

Role of individual phosphorylation sites for the 14-3-3-protein-dependent activation of yeast neutral trehalase Nth1

Crystal structure of the enzyme CapF of Staphylococcus aureus reveals a unique architecture composed of two functional domains

Degradation of mutant huntingtin via the ubiquitin/proteasome system is modulated by FE65

Cross-talk between TGFβ1 and EGFR signalling pathways induces TM4SF5 expression and epithelial–mesenchymal transition

Conformational transitions of proteins engaged in DNA double-strand break repair, analysed by tryptophan fluorescence emission and FRET

Cadherin binding is not a limiting step for Bacillus thuringiensis subsp. israelensis Cry4Ba toxicity to Aedes aegypti larvae

Toxic prefibrillar α-synuclein amyloid oligomers adopt a distinctive antiparallel β-sheet structure

Characterization of and functional evidence for Ste27 of Streptomyces sp. 139 as a novel spermine/spermidine acetyltransferase

CS055 (Chidamide/HBI-8000), a novel histone deacetylase inhibitor, induces G₁ arrest, ROS-dependent apoptosis and differentiation in human leukaemia cells

Cytosolic Ca²⁺ regulates the energization of isolated brain mitochondria by formation of pyruvate through the malate–aspartate shuttle

The novel function of HINFP as a co-activator in sterol-regulated transcription of PCSK9 in HepG2 cells

Transthyretin is a metallopeptidase with an inducible active site

The mouse Mageb18 gene encodes a ubiquitously expressed type I MAGE protein and regulates cell proliferation and apoptosis in melanoma B16-F0 cells

Indian Hedgehog signalling triggers Nkx3.2 protein degradation during chondrocyte maturation

Pref-1 in brown adipose tissue: specific involvement in brown adipocyte differentiation and regulatory role of C/EBPδ

p53 Ser¹⁵ phosphorylation disrupts the p53–RPA70 complex and induces RPA70-mediated DNA repair in hypoxia

Induction of NANOG expression by targeting promoter sequence with small activating RNA antagonizes retinoic acid-induced differentiation

Fasting induces ketoacidosis and hypothermia in PDHK2/PDHK4-double-knockout mice

The ligand specificity of the G-protein-coupled receptor GPR34

Accelerated Publications

Ivermectin is a specific inhibitor of importin α/β-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus

Research articles

Isoform-selective induction of human p110δ PI3K expression by TNFα: identification of a new and inducible PIK3CD promoter

Commentaries

Pref-1 preferentially inhibits heat production in brown adipose tissue

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