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Volume 462, Issue 1

August 2014

All Issues

Cover Image

Cover Image
Front Matter
Table of Contents
Editorial Board

ISSN 0264-6021

EISSN 1470-8728

In this Issue

Review articles
Research articles
Commentarys

Review articles

The molecular regulation of Janus kinase (JAK) activation

Jeffrey J. Babon; Isabelle S. Lucet; James M. Murphy; Nicos A. Nicola; Leila N. Varghese

Biochem J (2014) 462 (1): 1–13.

Abstract

View Articletitled, The molecular regulation of Janus kinase (JAK) activation

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TALEN-mediated genome editing: prospects and perspectives

David A. Wright; Ting Li; Bing Yang; Martin H. Spalding

Biochem J (2014) 462 (1): 15–24.

Abstract

View Articletitled, TALEN-mediated genome editing: prospects and perspectives

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Research articles

Chaperone protein involved in transmembrane transport of iron

Izumi Yanatori; Yumiko Yasui; Mitsuaki Tabuchi; Fumio Kishi

Biochem J (2014) 462 (1): 25–37.

Abstracts

View Articletitled, Chaperone protein involved in transmembrane transport of iron

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Structural and enzymatic insights into Lambda glutathione transferases from Populus trichocarpa, monomeric enzymes constituting an early divergent class specific to terrestrial plants

Pierre-Alexandre Lallement; Edgar Meux; José M. Gualberto; Pascalita Prosper; Claude Didierjean; Frederick Saul; Ahmed Haouz; Nicolas Rouhier; Arnaud Hecker

Biochem J (2014) 462 (1): 39–52.

Abstracts

View Articletitled, Structural and enzymatic insights into Lambda glutathione transferases from Populus trichocarpa, monomeric enzymes constituting an early divergent class specific to terrestrial plants

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Structural analysis of poly-SUMO chain recognition by the RNF4-SIMs domain

Camy C.-H. Kung; Mandar T. Naik; Szu-Huan Wang; Hsiu-Ming Shih; Che-Chang Chang; Li-Ying Lin; Chia-Lin Chen; Che Ma; Chi-Fon Chang; Tai-Huang Huang

Biochem J (2014) 462 (1): 53–65.

Abstracts

View Articletitled, Structural analysis of poly-SUMO chain recognition by the RNF4-SIMs domain

Supplementary data

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Impaired selenoprotein expression in brain triggers striatal neuronal loss leading to co-ordination defects in mice

Sandra Seeher; Bradley A. Carlson; Angela C. Miniard; Eva K. Wirth; Yassin Mahdi; Dolph L. Hatfield; Donna M. Driscoll; Ulrich Schweizer

Biochem J (2014) 462 (1): 67–75.

Abstracts

View Articletitled, Impaired selenoprotein expression in brain triggers striatal neuronal loss leading to co-ordination defects in mice

Supplementary data

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Lysine methylation is an endogenous post-translational modification of tau protein in human brain and a modulator of aggregation propensity

Kristen E. Funk; Stefani N. Thomas; Kelsey N. Schafer; Grace L. Cooper; Zhongping Liao; David J. Clark; Austin J. Yang; Jeff Kuret

Biochem J (2014) 462 (1): 77–88.

Abstracts

View Articletitled, Lysine methylation is an endogenous post-translational modification of tau protein in human brain and a modulator of aggregation propensity

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TM4SF5 suppression disturbs integrin α5-related signalling and muscle development in zebrafish

Yoon-Ju Choi; Hyun Ho Kim; Jeong-gyun Kim; Hye-Jin Kim; Minkyung Kang; Mi-Sook Lee; Jihye Ryu; Haeng Eun Song; Seo Hee Nam; Doohyung Lee; Kyu-Won Kim; Jung Weon Lee

Biochem J (2014) 462 (1): 89–101.

Abstracts

View Articletitled, TM4SF5 suppression disturbs integrin α5-related signalling and muscle development in zebrafish

Supplementary data

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miR-21/DDAH1 pathway regulates pulmonary vascular responses to hypoxia

Lucio Iannone; Lan Zhao; Olivier Dubois; Lucie Duluc; Christopher J. Rhodes; John Wharton; Martin R. Wilkins; James Leiper; Beata Wojciak-Stothard

Biochem J (2014) 462 (1): 103–112.

Abstracts

View Articletitled, miR-21/DDAH1 pathway regulates pulmonary vascular responses to hypoxia

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Fibrin binds to collagen and provides a bridge for αVβ3 integrin-dependent contraction of collagen gels

Vahid Reyhani; Pegah Seddigh; Bengt Guss; Renata Gustafsson; Lars Rask; Kristofer Rubin

Biochem J (2014) 462 (1): 113–123.

Abstracts

View Articletitled, Fibrin binds to collagen and provides a bridge for αVβ3 integrin-dependent contraction of collagen gels

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Protein kinase inhibitor β enhances the constitutive activity of G-protein-coupled zinc receptor GPR39

Zsuzsa Kovacs; Teresa Schacht; Ann-Kathrin Herrmann; Philipp Albrecht; Konstantinos Lefkimmiatis; Axel Methner

Biochem J (2014) 462 (1): 125–132.

Abstracts

View Articletitled, Protein kinase inhibitor β enhances the constitutive activity of G-protein-coupled zinc receptor GPR39

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Cellular mechanisms underlying the increased disease severity seen for patients with long QT syndrome caused by compound mutations in KCNQ1

Stephen C. Harmer; Jagdeep S. Mohal; Alice A. Royal; William J. McKenna; Pier D. Lambiase; Andrew Tinker

Biochem J (2014) 462 (1): 133–142.

Abstracts

View Articletitled, Cellular mechanisms underlying the increased disease severity seen for patients with long QT syndrome caused by compound mutations in KCNQ1

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N-terminus of the protein kinase CLK1 induces SR protein hyperphosphorylation

Brandon E. Aubol; Ryan M. Plocinik; Malik M. Keshwani; Maria L. McGlone; Jonathan C. Hagopian; Gourisankar Ghosh; Xiang-Dong Fu; Joseph A. Adams

Biochem J (2014) 462 (1): 143–152.

Abstracts

View Articletitled, N-terminus of the protein kinase CLK1 induces SR protein hyperphosphorylation

Supplementary data

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Identification and characterization of a mirror-image oligonucleotide that binds and neutralizes sphingosine 1-phosphate, a central mediator of angiogenesis

Werner G. Purschke; Kai Hoehlig; Klaus Buchner; Dirk Zboralski; Frank Schwoebel; Axel Vater; Sven Klussmann

Biochem J (2014) 462 (1): 153–162.

Abstracts

View Articletitled, Identification and characterization of a mirror-image oligonucleotide that binds and neutralizes sphingosine 1-phosphate, a central mediator of angiogenesis

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Rate of steroid double-bond reduction catalysed by the human steroid 5β-reductase (AKR1D1) is sensitive to steroid structure: implications for steroid metabolism and bile acid synthesis

Yi Jin; Mo Chen; Trevor M. Penning

Biochem J (2014) 462 (1): 163–171.

Abstracts

View Articletitled, Rate of steroid double-bond reduction catalysed by the human steroid 5β-reductase (AKR1D1) is sensitive to steroid structure: implications for steroid metabolism and bile acid synthesis

Supplementary data

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Discovery of InsP₆-kinases as InsP₆-dephosphorylating enzymes provides a new mechanism of cytosolic InsP₆ degradation driven by the cellular ATP/ADP ratio

Torsten Wundenberg; Nicole Grabinski; Hongying Lin; Georg W. Mayr

Biochem J (2014) 462 (1): 173–184.

Abstracts

View Articletitled, Discovery of InsP6-kinases as InsP6-dephosphorylating enzymes provides a new mechanism of cytosolic InsP6 degradation driven by the cellular ATP/ADP ratio

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Reversible disassembly of the yeast V-ATPase revisited under in vivo conditions

Katharina Tabke; Andrea Albertmelcher; Olga Vitavska; Markus Huss; Hans-Peter Schmitz; Helmut Wieczorek

Biochem J (2014) 462 (1): 185–197.

Abstracts

View Articletitled, Reversible disassembly of the yeast V-ATPase revisited under in vivo conditions

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Commentarys

Chaperone turns gatekeeper: PCBP2 and DMT1 form an iron-transport pipeline

Darius J. R. Lane; Des R. Richardson

Biochem J (2014) 462 (1): e1–e3.

Abstract

View Articletitled, Chaperone turns gatekeeper: PCBP2 and DMT1 form an iron-transport pipeline

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Trypanosomatid histones: the building blocks of the epigenetic code of highly divergent eukaryotes

Insights into the cellular function and mechanism of action of quinone reductase 2 (NQO2)

Effect of methyl DNA adducts on 3’-5’ exonuclease activity of human TREX1

Signalling by co-operative higher-order assembly formation: linking evidence at molecular and cellular levels

Aldose reductase, fructose and fat production in the liver

Review articles

The molecular regulation of Janus kinase (JAK) activation

TALEN-mediated genome editing: prospects and perspectives

Research articles

Chaperone protein involved in transmembrane transport of iron

Structural and enzymatic insights into Lambda glutathione transferases from Populus trichocarpa, monomeric enzymes constituting an early divergent class specific to terrestrial plants

Structural analysis of poly-SUMO chain recognition by the RNF4-SIMs domain

Impaired selenoprotein expression in brain triggers striatal neuronal loss leading to co-ordination defects in mice

Lysine methylation is an endogenous post-translational modification of tau protein in human brain and a modulator of aggregation propensity

TM4SF5 suppression disturbs integrin α5-related signalling and muscle development in zebrafish

miR-21/DDAH1 pathway regulates pulmonary vascular responses to hypoxia

Fibrin binds to collagen and provides a bridge for αVβ3 integrin-dependent contraction of collagen gels

Protein kinase inhibitor β enhances the constitutive activity of G-protein-coupled zinc receptor GPR39

Cellular mechanisms underlying the increased disease severity seen for patients with long QT syndrome caused by compound mutations in KCNQ1

N-terminus of the protein kinase CLK1 induces SR protein hyperphosphorylation

Identification and characterization of a mirror-image oligonucleotide that binds and neutralizes sphingosine 1-phosphate, a central mediator of angiogenesis

Rate of steroid double-bond reduction catalysed by the human steroid 5β-reductase (AKR1D1) is sensitive to steroid structure: implications for steroid metabolism and bile acid synthesis

Discovery of InsP₆-kinases as InsP₆-dephosphorylating enzymes provides a new mechanism of cytosolic InsP₆ degradation driven by the cellular ATP/ADP ratio

Reversible disassembly of the yeast V-ATPase revisited under in vivo conditions

Commentarys

Chaperone turns gatekeeper: PCBP2 and DMT1 form an iron-transport pipeline

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