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Volume 466, Issue 2

March 2015

All Issues

Cover Image

Cover Image
Front Matter
Table of Contents
Editorial Board

ISSN 0264-6021

EISSN 1470-8728

In this Issue

Review articles
Research articles
Accelerated Publications

Review articles

Pancreatic β-cell identity, glucose sensing and the control of insulin secretion

Guy A. Rutter; Timothy J. Pullen; David J. Hodson; Aida Martinez-Sanchez

Biochem J (2015) 466 (2): 203–218.

Abstracts

View Articletitled, Pancreatic β-cell identity, glucose sensing and the control of insulin secretion

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Comparative structural analysis of the caspase family with other clan CD cysteine peptidases

Karen McLuskey; Jeremy C. Mottram

Biochem J (2015) 466 (2): 219–232.

Abstract

View Articletitled, Comparative structural analysis of the caspase family with other clan CD cysteine peptidases

Supplementary data

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Research articles

Cu²⁺ accentuates distinct misfolding of Aβ_(1–40) and Aβ_(1–42) peptides, and potentiates membrane disruption

Christian J. Matheou; Nadine D. Younan; John H. Viles

Biochem J (2015) 466 (2): 233–242.

Abstracts

View Articletitled, Cu2+ accentuates distinct misfolding of Aβ(1–40) and Aβ(1–42) peptides, and potentiates membrane disruption

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Kinetic characterization of a cocaine hydrolase engineered from mouse butyrylcholinesterase

Xiabin Chen; Xiaoqin Huang; Liyi Geng; Liu Xue; Shurong Hou; Xirong Zheng; Stephen Brimijoin; Fang Zheng; Chang-Guo Zhan

Biochem J (2015) 466 (2): 243–251.

Abstracts

View Articletitled, Kinetic characterization of a cocaine hydrolase engineered from mouse butyrylcholinesterase

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Catalytic surface radical in dye-decolorizing peroxidase: a computational, spectroscopic and site-directed mutagenesis study

Dolores Linde; Rebecca Pogni; Marina Cañellas; Fátima Lucas; Victor Guallar; Maria Camilla Baratto; Adalgisa Sinicropi; Verónica Sáez-Jiménez; Cristina Coscolín; Antonio Romero; Francisco Javier Medrano; Francisco J. Ruiz-Dueñas; Angel T. Martínez

Biochem J (2015) 466 (2): 253–262.

Abstracts

View Articletitled, Catalytic surface radical in dye-decolorizing peroxidase: a computational, spectroscopic and site-directed mutagenesis study

Supplementary data

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The sigma-1 receptors are present in monomeric and oligomeric forms in living cells in the presence and absence of ligands

Ashish K. Mishra; Timur Mavlyutov; Deo R. Singh; Gabriel Biener; Jay Yang; Julie A. Oliver; Arnold Ruoho; Valerică Raicu

Biochem J (2015) 466 (2): 263–271.

Abstracts

View Articletitled, The sigma-1 receptors are present in monomeric and oligomeric forms in living cells in the presence and absence of ligands

Supplementary data

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Proline dehydrogenase 2 (PRODH2) is a hydroxyproline dehydrogenase (HYPDH) and molecular target for treating primary hyperoxaluria

Candice B. Summitt; Lynnette C. Johnson; Thomas J. Jönsson; Derek Parsonage; Ross P. Holmes; W. Todd Lowther

Biochem J (2015) 466 (2): 273–281.

Abstracts

View Articletitled, Proline dehydrogenase 2 (PRODH2) is a hydroxyproline dehydrogenase (HYPDH) and molecular target for treating primary hyperoxaluria

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FoxO1 negatively regulates leptin-induced POMC transcription through its direct interaction with STAT3

Wei Ma; Gloria Fuentes; Xiaohe Shi; Chandra Verma; George K. Radda; Weiping Han

Biochem J (2015) 466 (2): 291–298.

Abstracts

View Articletitled, FoxO1 negatively regulates leptin-induced POMC transcription through its direct interaction with STAT3

Supplementary data

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The solution structure of the MANEC-type domain from hepatocyte growth factor activator inhibitor-1 reveals an unexpected PAN/apple domain-type fold

Zebin Hong; Michal Nowakowski; Chris Spronk; Steen V. Petersen; Peter A. Andreasen; Wiktor Koźmiński; Frans A.A. Mulder; Jan K. Jensen

Biochem J (2015) 466 (2): 299–309.

Abstracts

View Articletitled, The solution structure of the MANEC-type domain from hepatocyte growth factor activator inhibitor-1 reveals an unexpected PAN/apple domain-type fold

Supplementary data

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Conserved proline-directed phosphorylation regulates SR protein conformation and splicing function

Malik M. Keshwani; Brandon E. Aubol; Laurent Fattet; Chen-Ting Ma; Jinsong Qiu; Patricia A. Jennings; Xiang-Dong Fu; Joseph A. Adams

Biochem J (2015) 466 (2): 311–322.

Abstracts

View Articletitled, Conserved proline-directed phosphorylation regulates SR protein conformation and splicing function

Supplementary data

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Expression of different bacterial cytotoxins is controlled by two global transcription factors, CRP and Fis, that co-operate in a shared-recruitment mechanism

Amanda E. Rossiter; Rita E. Godfrey; Jack A. Connolly; Stephen J. W. Busby; Ian R. Henderson; Douglas F. Browning

Biochem J (2015) 466 (2): 323–335.

Abstracts

View Articletitled, Expression of different bacterial cytotoxins is controlled by two global transcription factors, CRP and Fis, that co-operate in a shared-recruitment mechanism

Supplementary data

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Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2

Guillaume Poncet-Montange; Yanai Zhan; Jennifer P. Bardenhagen; Alessia Petrocchi; Elisabetta Leo; Xi Shi; Gilbert R. Lee, IV; Paul G. Leonard; Mary K. Geck Do; Mario G. Cardozo; Jannik N. Andersen; Wylie S. Palmer; Philip Jones; John E. Ladbury

Biochem J (2015) 466 (2): 337–346.

Abstracts

View Articletitled, Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2

Supplementary data

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The regulatory role of Streptomyces coelicolor TamR in central metabolism

Hao Huang; Smitha Sivapragasam; Anne Grove

Biochem J (2015) 466 (2): 347–358.

Abstracts

View Articletitled, The regulatory role of Streptomyces coelicolor TamR in central metabolism

Supplementary data

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The function of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) explored using a specific inhibitor that targets the PI5P-binding site

Jonathan H. Clarke; Maria-Luisa Giudici; John E. Burke; Roger L. Williams; David J. Maloney; Juan Marugan; Robin F. Irvine

Biochem J (2015) 466 (2): 359–367.

Abstracts

View Articletitled, The function of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) explored using a specific inhibitor that targets the PI5P-binding site

Supplementary data

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C/EBP homologous protein (CHOP) contributes to hepatocyte death via the promotion of ERO1α signalling in acute liver failure

Jianhua Rao; Chuangyong Zhang; Ping Wang; Ling Lu; Xiaofeng Qian; Jianjie Qin; Xiongxiong Pan; Guoqiang Li; Xuehao Wang; Feng Zhang

Biochem J (2015) 466 (2): 369–378.

Abstracts

View Articletitled, C/EBP homologous protein (CHOP) contributes to hepatocyte death via the promotion of ERO1α signalling in acute liver failure

Supplementary data

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Steatosis inhibits liver cell store-operated Ca²⁺ entry and reduces ER Ca²⁺ through a protein kinase C-dependent mechanism

Claire H. Wilson; Eunüs S. Ali; Nathan Scrimgeour; Alyce M. Martin; Jin Hua; George A. Tallis; Grigori Y. Rychkov; Greg J. Barritt

Biochem J (2015) 466 (2): 379–390.

Abstracts

View Articletitled, Steatosis inhibits liver cell store-operated Ca2+ entry and reduces ER Ca2+ through a protein kinase C-dependent mechanism

Supplementary data

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Bombyx mori prothoracicostatic peptide receptor is allosterically activated via a Gα_i/o-protein-biased signalling cascade by Drosophila sex peptide

Xiaobai He; Jiashu Zang; Huipeng Yang; Haishan Huang; Ying Shi; Chenggang Zhu; Naiming Zhou

Biochem J (2015) 466 (2): 391–400.

Abstracts

View Articletitled, Bombyx mori prothoracicostatic peptide receptor is allosterically activated via a Gαi/o-protein-biased signalling cascade by Drosophila sex peptide

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Iron alters cell survival in a mitochondria-dependent pathway in ovarian cancer cells

Kyle Bauckman; Edward Haller; Nicholas Taran; Stephanie Rockfield; Abigail Ruiz-Rivera; Meera Nanjundan

Biochem J (2015) 466 (2): 401–413.

Abstracts

View Articletitled, Iron alters cell survival in a mitochondria-dependent pathway in ovarian cancer cells

Supplementary data

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Andrographolide activates the canonical Wnt signalling pathway by a mechanism that implicates the non-ATP competitive inhibition of GSK-3β: autoregulation of GSK-3β in vivo

Cheril Tapia-Rojas; Andreas Schüller; Carolina B. Lindsay; Roxana C. Ureta; Cristóbal Mejías-Reyes; Juan Hancke; Francisco Melo; Nibaldo C. Inestrosa

Biochem J (2015) 466 (2): 415–430.

Abstracts

View Articletitled, Andrographolide activates the canonical Wnt signalling pathway by a mechanism that implicates the non-ATP competitive inhibition of GSK-3β: autoregulation of GSK-3β in vivo

Supplementary data

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Accelerated Publications

Trehalose-6-phosphate synthase 1 is not the only active TPS in Arabidopsis thaliana

Ines Delorge; Carlos M. Figueroa; Regina Feil; John E. Lunn; Patrick Van Dijck

Biochem J (2015) 466 (2): 283–290.

Abstracts

View Articletitled, Trehalose-6-phosphate synthase 1 is not the only active TPS in Arabidopsis thaliana

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Exploring the dynamics and interactions of the N-myc transactivation domain through solution NMR

Key structural role of a conserved cis-proline revealed by the P285S variant of soybean serine hydroxymethyltransferase 8

Histone deacetylase 7 activates 6-phosphogluconate dehydrogenase via an enzyme-independent mechanism that involves the N-terminal protein-protein interaction domain

Filamin A regulates platelet shape change and contractile force generation via phosphorylation of the myosin light chain

Revamped role for approved drug: integrative computational and biophysical analysis of saquinavir's peptidyl arginine deiminase 4 inhibition for rheumatoid arthritis

Review articles

Pancreatic β-cell identity, glucose sensing and the control of insulin secretion

Comparative structural analysis of the caspase family with other clan CD cysteine peptidases

Research articles

Cu²⁺ accentuates distinct misfolding of Aβ_(1–40) and Aβ_(1–42) peptides, and potentiates membrane disruption

Kinetic characterization of a cocaine hydrolase engineered from mouse butyrylcholinesterase

Catalytic surface radical in dye-decolorizing peroxidase: a computational, spectroscopic and site-directed mutagenesis study

The sigma-1 receptors are present in monomeric and oligomeric forms in living cells in the presence and absence of ligands

Proline dehydrogenase 2 (PRODH2) is a hydroxyproline dehydrogenase (HYPDH) and molecular target for treating primary hyperoxaluria

FoxO1 negatively regulates leptin-induced POMC transcription through its direct interaction with STAT3

The solution structure of the MANEC-type domain from hepatocyte growth factor activator inhibitor-1 reveals an unexpected PAN/apple domain-type fold

Conserved proline-directed phosphorylation regulates SR protein conformation and splicing function

Expression of different bacterial cytotoxins is controlled by two global transcription factors, CRP and Fis, that co-operate in a shared-recruitment mechanism

Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2

The regulatory role of Streptomyces coelicolor TamR in central metabolism

The function of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) explored using a specific inhibitor that targets the PI5P-binding site

C/EBP homologous protein (CHOP) contributes to hepatocyte death via the promotion of ERO1α signalling in acute liver failure

Steatosis inhibits liver cell store-operated Ca²⁺ entry and reduces ER Ca²⁺ through a protein kinase C-dependent mechanism

Bombyx mori prothoracicostatic peptide receptor is allosterically activated via a Gα_i/o-protein-biased signalling cascade by Drosophila sex peptide

Iron alters cell survival in a mitochondria-dependent pathway in ovarian cancer cells

Andrographolide activates the canonical Wnt signalling pathway by a mechanism that implicates the non-ATP competitive inhibition of GSK-3β: autoregulation of GSK-3β in vivo

Accelerated Publications

Trehalose-6-phosphate synthase 1 is not the only active TPS in Arabidopsis thaliana

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