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Issues

ISSN 0264-6021
EISSN 1470-8728
In this Issue

Review Articles

Biochemical Journal (1 June 2017) 474 (11): 1755–1768.
Biochemical Journal (1 June 2017) 474 (11): 1823–1836.

Commentaries

Biochemical Journal (1 June 2017) 474 (11): 1803–1806.

Research Articles

Biochemical Journal (1 June 2017) 474 (11): 1769–1787.
Biochemical Journal (1 June 2017) 474 (11): 1789–1801.
Biochemical Journal (1 June 2017) 474 (11): 1807–1821.
Biochemical Journal (1 June 2017) 474 (11): 1837–1852.
Biochemical Journal (1 June 2017) 474 (11): 1853–1866.
Biochemical Journal (1 June 2017) 474 (11): 1867–1877.
Biochemical Journal (1 June 2017) 474 (11): 1879–1895.
Biochemical Journal (1 June 2017) 474 (11): 1897–1918.
Biochemical Journal (1 June 2017) 474 (11): 1919–1934.
  • Cover Image

    Cover Image

    issue cover

    Atrial natriuretic peptide (ANP) is a cardiac hormone released by the atrium in response to stretching forces. ANP, which maintains cardiovascular homeostasis via its diuretic, natriuretic and hypotensive effects, acts through its receptor, GC-A. In this issue of the Biochemical Journal, Miura et al. (pages 1897–1918) established mouse immortalized endothelial cells stably expressing GC-A (SVEC/GC-A) and found that ANP promotes cell spreading and endothelial barrier function via regulation of CCM2, an adaptor protein involved in the pathogenesis of cerebral cavernous malformations, a neurovascular disease characterized by dysfunction of the endothelial barrier. The image shows ANP promotes co-localization of GC-A (green) and CCM2 (red) at membrane ruffles in SVEC/GC-A. Image kindly provided by Koichi Miura

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