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June 2017
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α-synuclein is an abundant presynaptic protein and, when misfolded, is well known to be involved in neurodegenerative disease such as Parkinson's and Lewy body dementia. However, the normal function of α-synuclein in the brain remains unknown. In this issue of the Biochemical Journal, Lou et al. showed that α-synuclein is able to promote SNARE-dependent vesicles docking by concurrently interacting with the v-SNARE and negatively charged lipid on opposite vesicles. For more information, please see article by Xiaochu Lou et al, pages 2039–2049.
ISSN 0264-6021
EISSN 1470-8728
In this Issue
Review Articles
The Slo(w) path to identifying the mitochondrial channels responsible for ischemic protection
Biochem J (2017) 474 (12): 2067–2094.
Research Articles
Global functions of extracellular, transmembrane and cytoplasmic domains of organic solute transporter β-subunit
Biochem J (2017) 474 (12): 1981–1992.
Probing native metal ion association sites through quenching of fluorophores in the nucleotide-binding domains of the ABC transporter MsbA
Daiki Tatsumi; Kei Nanatani; Yuto Koike; Kiyoto Kamagata; Satoshi Takahashi; Ayumu Konno; Tadaomi Furuta; Minoru Sakurai; Nobuyuki Uozumi
Biochem J (2017) 474 (12): 1993–2007.
The mechanism of activation of IRAK1 and IRAK4 by interleukin-1 and Toll-like receptor agonists
Stefan Vollmer; Sam Strickson; Tinghu Zhang; Nathanael Gray; Katherine L. Lee; Vikram R. Rao; Philip Cohen
Biochem J (2017) 474 (12): 2027–2038.
α-Synuclein may cross-bridge v-SNARE and acidic phospholipids to facilitate SNARE-dependent vesicle docking
Biochem J (2017) 474 (12): 2039–2049.
Encephalomyocarditis virus 3C protease attenuates type I interferon production through disrupting the TANK–TBK1–IKKε–IRF3 complex
Li Huang; Tao Xiong; Huibin Yu; Quan Zhang; Kunli Zhang; Changyao Li; Liang Hu; Yuanfeng Zhang; Lijie Zhang; Qinfang Liu; Shengnan Wang; Xijun He; Zhigao Bu; Xuehui Cai; Shangjin Cui; Jiangnan Li; Changjiang Weng
Biochem J (2017) 474 (12): 2051–2065.
1-N-histidine phosphorylation of ChlD by the AAA+ ChlI2 stimulates magnesium chelatase activity in chlorophyll synthesis
Biochem J (2017) 474 (12): 2095–2105.