Kinetochore–microtubule interactions in chromosome segregation: lessons from yeast and mammalian cells
Trz1, the long form RNase Z from yeast, forms a stable heterohexamer with endonuclease Nuc1 and mutarotase
Suppression of store-operated Ca2+ entry by activation of GPER: contribution to a clamping effect on endothelial Ca2+ signaling
An epifluorescence image of HEK293 cells expressing mKate2–GPER (red) and loaded with the Ca2+ indicator fura-2/AM (blue). The approach allows for direct comparison of Ca2+ signals in cells transfected with or without mKate2–GPER in the same microscopic field. In this issue of the Biochemical Journal, Terry et al. report on how activation of GPER (G protein-coupled estrogen receptor 1) “clamps” cytoplasmic Ca2+ signals via suppression of store-operated Ca2+ entry and Ca2+ efflux; see pages 3627–3642 for details.